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Literature DB >> 16647712

A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells.

Yang Liu¹, Randal D Goff, Dapeng Zhou, Jochen Mattner, Barbara A Sullivan, Archana Khurana, Carlos Cantu, Eugene V Ravkov, Chris C Ibegbu, John D Altman, Luc Teyton, Albert Bendelac, Paul B Savage.

Abstract

CD1d presentation of alpha-galactosyl ceramides to natural killer T cells has been a focal point of the study of regulatory T cells. KRN7000, an alpha-galactosyl ceramide originally generated from structure activity studies of antitumor properties of marine sponge glycolipids, is currently the most commonly used agonist ligand and is used to stain NKT cells. However, this glycolipid suffers from poor solubility and availability. We have developed an alpha-galactosyl ceramide with improved solubility over KRN7000 that effectively stains NKT cells, both mouse and human, and stimulates cytokine release at low concentrations.

Entities: Chemical Gene Species

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Year: 2006 PMID： 16647712 DOI： 10.1016/j.jim.2006.02.009

Source DB: PubMed Journal: J Immunol Methods ISSN： 0022-1759 Impact factor: 2.303

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Cited

84 in total

1. A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo.

Authors: S Deng; L Bai; R Reboulet; R Matthew; D A Engler; L Teyton; A Bendelac; P B Savage
Journal: Chem Sci Date: 2014-04 Impact factor: 9.825

2. Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.

Authors: Marei Dose; Barry P Sleckman; Jin Han; Andrea L Bredemeyer; Albert Bendelac; Fotini Gounari
Journal: Proc Natl Acad Sci U S A Date: 2009-05-07 Impact factor: 11.205

3. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides.

Authors: Li Bai; Shenglou Deng; Rachel Reboulet; Rebecca Mathew; Luc Teyton; Paul B Savage; Albert Bendelac
Journal: Proc Natl Acad Sci U S A Date: 2013-09-16 Impact factor: 11.205

4. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.

Authors: Joao H F Pedra; Jochen Mattner; Jian Tao; Steven M Kerfoot; Roger J Davis; Richard A Flavell; Philip W Askenase; Zhinan Yin; Erol Fikrig
Journal: Infect Immun Date: 2007-11-12 Impact factor: 3.441

5. Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells.

Authors: Ning Yin; Xiangtian Long; Randal D Goff; Dapeng Zhou; Carlos Cantu; Jochen Mattner; Pierre Saint Mezard; Luc Teyton; Albert Bendelac; Paul B Savage
Journal: ACS Chem Biol Date: 2009-03-20 Impact factor: 5.100

6. An alpha-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes.

Authors: D Ly; R Tohn; B Rubin; H Blumenfeld; G S Besra; N Veerapen; S A Porcelli; T L Delovitch
Journal: Clin Exp Immunol Date: 2009-12-15 Impact factor: 4.330

A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells.

1. A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo.

2. Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.

3. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides.

4. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.

5. Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells.

6. An alpha-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes.

7. Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade.

8. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties.

9. Scavenger receptors target glycolipids for natural killer T cell activation.

10. Regulatory roles for NKT cell ligands in environmentally induced autoimmunity.