Literature DB >> 1664765

CP-93,129, a potent and selective 5-HT1B receptor agonist blocks neurogenic plasma extravasation within rat but not guinea-pig dura mater.

T Matsubara1, M A Moskowitz, B Byun.   

Abstract

Pretreatment with CP-93,129 blocked plasma extravasation in rat dura mater induced by electrical trigeminal ganglion stimulation when administered at greater than or equal to 140 nmol kg-1, i.v. but did not affect plasma leakage in guinea-pig at 460 or 1400 nmol kg-1. Sumatriptan, a 5-HT1D-like receptor agonist, blocked plasma extravasation in the guinea-pig model when administered at 7 nmol kg-1. In as much as CP-93,129 binds with micromolar affinities to 5-HT1A, 5-HT1C, 5-HT1D, and 5-HT2 recognition sites, and with nanomolar affinity to the 5-HT1B receptor subtype, blockade of plasma extravasation in the rat dura mater may be mediated by 5-HT1B receptors whereas the 5-HT1D receptor may be more relevant to the guinea-pig.

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Year:  1991        PMID： 1664765      PMCID： PMC1908303          DOI： 10.1111/j.1476-5381.1991.tb12374.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

Review 1.  Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain.

Authors:  D Hoyer; D N Middlemiss
Journal:  Trends Pharmacol Sci       Date:  1989-04       Impact factor: 14.819

2.  Ergot alkaloids block neurogenic extravasation in dura mater: proposed action in vascular headaches.

Authors:  K Saito; S Markowitz; M A Moskowitz
Journal:  Ann Neurol       Date:  1988-12       Impact factor: 10.422

3.  The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater.

Authors:  M G Buzzi; M A Moskowitz
Journal:  Br J Pharmacol       Date:  1990-01       Impact factor: 8.739

4.  Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain.

Authors:  S Markowitz; K Saito; M A Moskowitz
Journal:  J Neurosci       Date:  1987-12       Impact factor: 6.167

5.  3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.

Authors:  J E Macor; C A Burkhart; J H Heym; J L Ives; L A Lebel; M E Newman; J A Nielsen; K Ryan; D W Schulz; L K Torgersen
Journal:  J Med Chem       Date:  1990-08       Impact factor: 7.446
  5 in total
  8 in total

1.  Effect of a 5-HT1 receptor agonist, CP-122,288, on oedema formation induced by stimulation of the rat saphenous nerve.

Authors:  R Kajekar; P Gupta; N B Shepperson; S D Brain
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

2.  Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.

Authors:  J-D Guo; D G Rainnie
Journal:  Neuroscience       Date:  2009-12-03       Impact factor: 3.590

Review 3.  Migraine: where and how does the pain originate?

Authors:  Karl Messlinger
Journal:  Exp Brain Res       Date:  2009-03-14       Impact factor: 1.972

4.  Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development.

Authors:  G W Rebeck; K I Maynard; B T Hyman; M A Moskowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

5.  CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges.

Authors:  K Nozaki; M A Moskowitz; P Boccalini
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

6.  Blockade by oral or parenteral RPR 100893 (a non-peptide NK1 receptor antagonist) of neurogenic plasma protein extravasation within guinea-pig dura mater and conjunctiva.

Authors:  W S Lee; S M Moussaoui; M A Moskowitz
Journal:  Br J Pharmacol       Date:  1994-07       Impact factor: 8.739

7.  Time-dependent blockade of neurogenic plasma extravasation in dura mater by 5-HT1B/D agonists and endopeptidase 24.11.

Authors:  Z Huang; B Byun; T Matsubara; M A Moskowitz
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

8.  Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor.

Authors:  J K Ward; A J Fox; P J Barnes; M G Belvisi
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739
  8 in total

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