OBJECTIVES: To evaluate the relationships between laryngeal inflammation assessed using the Reflux Finding Score (RFS), laryngeal sensory function, and apnea severity in patients with obstructive sleep apnea (OSA). METHODS: Endoscopic sensory testing (EST) was performed with subsequent blinded scoring from video of RFS. An RFS>7 was indicative of increased inflammatory change. RESULTS: Of 34 patients evaluated, 29 had OSA (apnea-hypopnea index [AHI]>or=15 events/h) at polysomnography. Increased inflammation was present in 26/29 (90%), with changes suggestive of laryngopharyngeal reflux. There were significant correlations between: inflammation and OSA severity (eg, RFS vs AHI, r=0.57, P<0.001); inflammation and laryngeal sensory impairment (EST detection threshold and pressure required to elicit the laryngeal adductor reflex, LAR); and the degree of sensory impairment and OSA severity. CONCLUSIONS: Laryngeal inflammation is prevalent among OSA patients and correlates with laryngeal sensory dysfunction, attenuation of the LAR, and apnea severity. EBM RATING: C-4.
OBJECTIVES: To evaluate the relationships between laryngeal inflammation assessed using the Reflux Finding Score (RFS), laryngeal sensory function, and apnea severity in patients with obstructive sleep apnea (OSA). METHODS: Endoscopic sensory testing (EST) was performed with subsequent blinded scoring from video of RFS. An RFS>7 was indicative of increased inflammatory change. RESULTS: Of 34 patients evaluated, 29 had OSA (apnea-hypopnea index [AHI]>or=15 events/h) at polysomnography. Increased inflammation was present in 26/29 (90%), with changes suggestive of laryngopharyngeal reflux. There were significant correlations between: inflammation and OSA severity (eg, RFS vs AHI, r=0.57, P<0.001); inflammation and laryngeal sensory impairment (EST detection threshold and pressure required to elicit the laryngeal adductor reflex, LAR); and the degree of sensory impairment and OSA severity. CONCLUSIONS:Laryngeal inflammation is prevalent among OSA patients and correlates with laryngeal sensory dysfunction, attenuation of the LAR, and apnea severity. EBM RATING: C-4.
Authors: Louis-Philippe Boulet; Qutayba Hamid; Simon L Bacon; Céline Bergeron; Louis-Philippe Boulet; Yue Chen; Anne E Dixon; Pierre Ernst; Qutayba Hamid; Fernando Holguin; Charles G Irvin; R John Kimoff; Sushma Komakula; Catherine Laprise; Kim L Lavoie; Stephanie A Shore; Mihaela Teodorescu; Marie-Claude Vohl Journal: Can Respir J Date: 2007 May-Jun Impact factor: 2.409
Authors: Eusebi Chiner; Mónica Llombart; Joan Valls; Esther Pastor; José N Sancho-Chust; Ada Luz Andreu; Manuel Sánchez-de-la-Torre; Ferran Barbé Journal: PLoS One Date: 2016-04-06 Impact factor: 3.240
Authors: Faisal Zawawi; Keith Richardson; Rickul Varshney; Jonathan Young; Alex M Mlynarek; Michael P Hier; Richard J Payne Journal: ISRN Otolaryngol Date: 2013-10-09