OBJECTIVE: Evaluate possible role of Helicobacter Pylori in pathogenesis of otitis media with effusion (OME). STUDY DESIGN AND SETTING: Randomized controlled trial, tertiary referral center. STUDY GROUP: Middle ear fluid was aspirated, a biopsy was taken from the promontorium of 22 children with OME. CONTROL GROUP: A small biopsy was taken from the promontorium of 20 children with normal otologic findings. For both groups, 5 mm deep tissue specimens were obtained from tonsil and adenoid. RESULTS: H pylori presence in the middle ear, the tonsillar and adenoid tissues by culture and PCR was significantly more frequent in the study group compared to the control group (P<0.05). CONCLUSIONS: This study is the first to grow H pylori in middle ear in OME. Significantly increased colonization by H pylori of the middle ear, and tonsillar and adenoid tissue in patients with OME indicates that the bacteria might be involved in the pathogenesis of OME. EBM RATING: A-1b.
RCT Entities:
OBJECTIVE: Evaluate possible role of Helicobacter Pylori in pathogenesis of otitis media with effusion (OME). STUDY DESIGN AND SETTING: Randomized controlled trial, tertiary referral center. STUDY GROUP: Middle ear fluid was aspirated, a biopsy was taken from the promontorium of 22 children with OME. CONTROL GROUP: A small biopsy was taken from the promontorium of 20 children with normal otologic findings. For both groups, 5 mm deep tissue specimens were obtained from tonsil and adenoid. RESULTS: H pylori presence in the middle ear, the tonsillar and adenoid tissues by culture and PCR was significantly more frequent in the study group compared to the control group (P<0.05). CONCLUSIONS: This study is the first to grow H pylori in middle ear in OME. Significantly increased colonization by H pylori of the middle ear, and tonsillar and adenoid tissue in patients with OME indicates that the bacteria might be involved in the pathogenesis of OME. EBM RATING: A-1b.
Authors: E Pavlík; P Lukes; B Potuzníková; J Astl; P Hrdá; A Soucek; P Matucha; J Dosedĕl; I Sterzl Journal: Folia Microbiol (Praha) Date: 2007 Impact factor: 2.099
Authors: Eva Nártová; Jaroslav Kraus; Emil Pavlík; Petr Lukeš; Rami Katra; Jan Plzák; Libuše Kolářová; Ivan Sterzl; Jan Betka; Jaromír Astl Journal: Eur Arch Otorhinolaryngol Date: 2013-07-18 Impact factor: 2.503
Authors: S Kariya; M Okano; K Fukushima; S Nomiya; Y Kataoka; R Nomiya; H Akagi; K Nishizaki Journal: Clin Exp Immunol Date: 2008-08-22 Impact factor: 4.330