| Literature DB >> 16647297 |
Abstract
The Fc epsilonRI-dependent activation of nuclear factor (NF)kappaB is key for mast-cell cytokine production. The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen receptors in lymphocytes. A recent study reveals that the Bcl10-Malt1 complex promotes mast-cell interleukin-6 and tumor necrosis factor production, independent of degranulation, eicosanoid secretion or survival. The new findings place this complex at the forefront in discriminating between signals required for cytokine production and those required for mast-cell degranulation and eicosanoid production.Entities:
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Year: 2006 PMID： 16647297 DOI： 10.1016/j.it.2006.04.001
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687