Yong-Qian Shu1, Yanhong Gu. 1. Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. yongqianshu@hotmail.com
Abstract
AIM: To study the effect of OK-432 on the maturation and function of human peripheral blood monocyte-derived dendritic cells, and the effect of these dendritic cells on the proliferation and anti-tumor function of cytokine induced killers. METHODS: Through the analysis of DCs' surface molecules, the detection of the proliferation and anti-tumor function of CIKs activated by DCs, we researched the influence of OK-432 on DCs and CIKs. RESULTS: OK-432 have the potential of promoting DCs to express CD1a, CD80, CD83, HLA-DR highly, which is stronger than LPS; DCs activated by OK-432 can facilitate the proliferation and function of CIKs. CONCLUSION: OK-432 can induce DCs' maturation and can thus promote CIKs' functions.
AIM: To study the effect of OK-432 on the maturation and function of human peripheral blood monocyte-derived dendritic cells, and the effect of these dendritic cells on the proliferation and anti-tumor function of cytokine induced killers. METHODS: Through the analysis of DCs' surface molecules, the detection of the proliferation and anti-tumor function of CIKs activated by DCs, we researched the influence of OK-432 on DCs and CIKs. RESULTS: OK-432 have the potential of promoting DCs to express CD1a, CD80, CD83, HLA-DR highly, which is stronger than LPS; DCs activated by OK-432 can facilitate the proliferation and function of CIKs. CONCLUSION: OK-432 can induce DCs' maturation and can thus promote CIKs' functions.
Authors: Changhee Yoo; Hyun-Ah Do; In Gab Jeong; Hongzoo Park; Jung-Jin Hwang; Jun Hyuk Hong; Jin Seon Cho; Myong-Soo Choo; Hanjong Ahn; Choung-Soo Kim Journal: J Korean Med Sci Date: 2010-08-14 Impact factor: 2.153