| Literature DB >> 16645095 |
Michelle M Riehle1, Kyriacos Markianos, Oumou Niaré, Jiannong Xu, Jun Li, Abdoulaye M Touré, Belco Podiougou, Frederick Oduol, Sory Diawara, Mouctar Diallo, Boubacar Coulibaly, Ahmed Ouatara, Leonid Kruglyak, Sékou F Traoré, Kenneth D Vernick.
Abstract
We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.Entities:
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Year: 2006 PMID： 16645095 DOI： 10.1126/science.1124153
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728