Literature DB >> 16644528

Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3).

Sung-Kyu Choi1, Hyun-Mi Oh, Su-Kyung Lee, Dae Gwin Jeong, Seong Eon Ryu, Kwang-Hee Son, Dong Cho Han, Nack-Do Sung, Nam-In Baek, Byoung-Mog Kwon.   

Abstract

Two biflavonoids, ginkgetin (1) and sciadopitysin (2), were isolated from the MeOH extract of the young branches of Taxus cuspidata, which inhibited phosphatase of regenerating liver-3 (PRL-3) with IC50 values of 25.8 and 46.2 microM, respectively. This is the first report on PRL-3 inhibitors, isolated from natural sources.

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Year:  2006        PMID： 16644528     DOI： 10.1080/14786410500463312

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  8 in total

Review 1.  Targeting protein tyrosine phosphatases for anticancer drug discovery.

Authors:  Latanya M Scott; Harshani R Lawrence; Saïd M Sebti; Nicholas J Lawrence; Jie Wu
Journal:  Curr Pharm Des       Date:  2010-06       Impact factor: 3.116

Review 2.  Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.).

Authors:  Dunja Šamec; Erna Karalija; Sabina Dahija; Sherif T S Hassan
Journal:  Plants (Basel)       Date:  2022-05-23

Review 3.  Phosphatase of regenerating liver: a novel target for cancer therapy.

Authors:  Amanda M Campbell; Zhong-Yin Zhang
Journal:  Expert Opin Ther Targets       Date:  2014-03-01       Impact factor: 6.902

Review 4.  The role and target potential of protein tyrosine phosphatases in cancer.

Authors:  Taolin Yi; Daniel Lindner
Journal:  Curr Oncol Rep       Date:  2008-03       Impact factor: 5.075

Review 5.  Targeting PTPs with small molecule inhibitors in cancer treatment.

Authors:  Zhong-Xing Jiang; Zhong-Yin Zhang
Journal:  Cancer Metastasis Rev       Date:  2008-06       Impact factor: 9.264

6.  Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver.

Authors:  Birgit Hoeger; Maren Diether; Pedro J Ballester; Maja Köhn
Journal:  Eur J Med Chem       Date:  2014-08-20       Impact factor: 6.514

Review 7.  Targeting phosphatases of regenerating liver (PRLs) in cancer.

Authors:  Min Wei; Konstantin V Korotkov; Jessica S Blackburn
Journal:  Pharmacol Ther       Date:  2018-06-05       Impact factor: 12.310

8.  Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer.

Authors:  Sigve Andersen; Elin Richardsen; Mehrdad Rakaee; Helena Bertilsson; Roy Bremnes; Magne Børset; Lill-Tove Busund; Tobias Slørdahl
Journal:  PLoS One       Date:  2017-11-30       Impact factor: 3.240
  8 in total

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