| Literature DB >> 16644494 |
Abstract
Rituximab was the first monoclonal antibody to have been registered for the treatment of B-cell lymphomas. Randomized studies have demonstrated its activity in follicular lymphoma, mantle-cell lymphoma, and diffuse large B-cell lymphoma in untreated or relapsing patients. Because of its high activity and low toxicity ratio, rituximab has transformed the outcome of patients with B-cell lymphoma. A combination of rituximab plus chemotherapy, R-CHOP, has the highest efficacy ever described with any chemotherapy in diffuse large B-cell lymphoma and follicular lymphoma. The role of radio-labelled antibodies is still to be defined.Entities:
Mesh:
Substances:
Year: 2006 PMID: 16644494 DOI: 10.1016/j.crvi.2005.12.006
Source DB: PubMed Journal: C R Biol ISSN: 1631-0691 Impact factor: 1.583