Literature DB >> 16644213

Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids.

Brent R Stranix1, Jean-François Lavallée, Guy Sévigny, Jocelyn Yelle, Valérie Perron, Nicholas LeBerre, Dominik Herbart, Jinzi J Wu.   

Abstract

A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.

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Year:  2006        PMID： 16644213     DOI： 10.1016/j.bmcl.2006.04.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

Review 1.  Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

Authors:  Arun K Ghosh; Heather L Osswald; Gary Prato
Journal:  J Med Chem       Date:  2016-01-22       Impact factor: 7.446

2.  Anti-proliferative effects of the combination of Sulfamethoxazole and Quercetin via caspase3 and NFkB gene regulation: an in vitro and in vivo study.

Authors:  Heba Abd Elghany Sahyon; Eman N M Ramadan; Fayez Althobaiti; Mohammad M A Mashaly
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2022-01-07       Impact factor: 3.000

3.  In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1.

Authors:  Serge Dandache; Guy Sévigny; Jocelyn Yelle; Brent R Stranix; Neil Parkin; Jonathan M Schapiro; Mark A Wainberg; Jinzi J Wu
Journal:  Antimicrob Agents Chemother       Date:  2007-07-16       Impact factor: 5.191

Review 4.  Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.

Authors:  Ashley N Matthew; Florian Leidner; Gordon J Lockbaum; Mina Henes; Jacqueto Zephyr; Shurong Hou; Desaboini Nageswara Rao; Jennifer Timm; Linah N Rusere; Debra A Ragland; Janet L Paulsen; Kristina Prachanronarong; Djade I Soumana; Ellen A Nalivaika; Nese Kurt Yilmaz; Akbar Ali; Celia A Schiffer
Journal:  Chem Rev       Date:  2021-01-07       Impact factor: 60.622

5.  Room temperature synthesis and antibacterial activity of new sulfonamides containing n,n-diethyl-substituted amido moieties.

Authors:  Olayinka O Ajani; Oluwole B Familoni; Feipeng Wu; Johnbull O Echeme; Zheng Sujiang
Journal:  Int J Med Chem       Date:  2012-10-17

6.  Bioactive Compounds of Ganoderma boninense Inhibited Methicillin-Resistant Staphylococcus aureus Growth by Affecting Their Cell Membrane Permeability and Integrity.

Authors:  Yow-San Chan; Khim-Phin Chong
Journal:  Molecules       Date:  2022-01-27       Impact factor: 4.411
  6 in total

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