Literature DB >> 1664412

A brain L-type calcium channel alpha 1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3.

H M Chin1, C A Kozak, H L Kim, B Mock, O W McBride.   

Abstract

A rat brain cDNA probe was used to localize a gene encoding the alpha 1 subunit of neuronal dihydropyridine-sensitive L-type calcium channels in the mouse and human genomes. Hybridization of the probe to Southern blots made with DNAs from a Chinese hamster x mouse somatic cell hybrid panel indicated that this gene maps to mouse chromosome 14 (Chr 14). Southern blot analysis of an intersubspecies cross demonstrated that the calcium channel alpha 1 subunit gene, termed Cchl1a2, can be positioned 7.5 cM proximal to Np-1. Similarly, segregation among human X rodent somatic cell hybrids indicated that CCHL1A2 maps to human chromosome 3. These assignments are consistent with a region of linkage homology between human chromosome 3p and a proximal region of mouse Chr 14.

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Year:  1991        PMID： 1664412     DOI： 10.1016/0888-7543(91)90014-6

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  10 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 2.  Mouse chromosome 14.

Authors:  J H Nadeau; R Cox
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.

Authors:  D L Burgess; C F Davis; L A Gefrides; J L Noebels
Journal:  Genome Res       Date:  1999-12       Impact factor: 9.043

4.  Genetic mapping of the gene encoding the alphal subunit of neuronal calcium channels.

Authors:  M S Lyu; C A Kozak; H Chin
Journal:  Mamm Genome       Date:  1996-04       Impact factor: 2.957

5.  Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart.

Authors:  D Schultz; G Mikala; A Yatani; D B Engle; D E Iles; B Segers; R J Sinke; D O Weghuis; U Klöckner; M Wakamori
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

6.  Genomic organization and chromosomal localization of the mouse synexin gene.

Authors:  Z Y Zhang-Keck; M Srivastava; C A Kozak; H Caohuy; A Shirvan; A L Burns; H B Pollard
Journal:  Biochem J       Date:  1994-08-01       Impact factor: 3.857

7.  Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

Authors:  T N Sato; Y Qin; C A Kozak; K L Audus
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

8.  Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.

Authors:  M E Greene; B Blumberg; O W McBride; H F Yi; K Kronquist; K Kwan; L Hsieh; G Greene; S D Nimer
Journal:  Gene Expr       Date:  1995

9.  Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits.

Authors:  J W Hell; R E Westenbroek; C Warner; M K Ahlijanian; W Prystay; M M Gilbert; T P Snutch; W A Catterall
Journal:  J Cell Biol       Date:  1993-11       Impact factor: 10.539

10.  Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neurons.

Authors:  J W Hell; C T Yokoyama; L J Breeze; C Chavkin; W A Catterall
Journal:  EMBO J       Date:  1995-07-03       Impact factor: 11.598
  10 in total

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