BACKGROUND: Altered serotonin (SERT) and dopamine transporter (DAT) densities have been recorded in major depression. Atypical depression (ATD) has been suggested to be connected to decreased serotonergic transmission, but no studies have been published on the association between brain serotonin transporter density and ATD. METHODS: PATIENTS with depression (n=29) were divided into three groups according to DSM-IV criteria: atypically depressed, melancholic patients, and "undifferentiated" patients. Depressive symptoms were evaluated with the 29-item Hamilton Depression Rating Scale (HAM-D-29). Single photon emission computed tomography (SPECT) with [(123)I]nor-beta-CIT was used to evaluate serotonin transporter density (SERT) in the midbrain and dopamine transporter density (DAT) in the striatum of patients and healthy controls (n=18). RESULTS: All subgroups except those with undifferentiated depression had lower SERT densities compared to controls. No significant differences were found in the densities between the subgroups. Atypical scores of HAM-D-29 were associated with SERT densities in the midbrain (beta=-0.40, t=-2.3, p=0.03), even after adjustment for age, gender and HAM-D-21 scores (beta=-0.39, t=-2.32, p=0.03). CONCLUSIONS: The association between atypical scores of HAM-D-29 and midbrain SERT densities suggests a relationship between serotonergic dysfunction and ATD.
BACKGROUND: Altered serotonin (SERT) and dopamine transporter (DAT) densities have been recorded in major depression. Atypical depression (ATD) has been suggested to be connected to decreased serotonergic transmission, but no studies have been published on the association between brain serotonin transporter density and ATD. METHODS:PATIENTS with depression (n=29) were divided into three groups according to DSM-IV criteria: atypically depressed, melancholic patients, and "undifferentiated" patients. Depressive symptoms were evaluated with the 29-item Hamilton Depression Rating Scale (HAM-D-29). Single photon emission computed tomography (SPECT) with [(123)I]nor-beta-CIT was used to evaluate serotonin transporter density (SERT) in the midbrain and dopamine transporter density (DAT) in the striatum of patients and healthy controls (n=18). RESULTS: All subgroups except those with undifferentiated depression had lower SERT densities compared to controls. No significant differences were found in the densities between the subgroups. Atypical scores of HAM-D-29 were associated with SERT densities in the midbrain (beta=-0.40, t=-2.3, p=0.03), even after adjustment for age, gender and HAM-D-21 scores (beta=-0.39, t=-2.32, p=0.03). CONCLUSIONS: The association between atypical scores of HAM-D-29 and midbrain SERT densities suggests a relationship between serotonergic dysfunction and ATD.
Authors: Manesh Gopaldas; Francesca Zanderigo; Serena Zhan; R Todd Ogden; Jeffrey M Miller; Harry Rubin-Falcone; Thomas B Cooper; Maria A Oquendo; Gregory Sullivan; J John Mann; M Elizabeth Sublette Journal: J Affect Disord Date: 2019-07-05 Impact factor: 4.839
Authors: Matthew S Milak; Ramin V Parsey; Leilani Lee; Maria A Oquendo; Doreen M Olvet; Francoise Eipper; Kevin Malone; J John Mann Journal: Psychiatry Res Date: 2009-05-14 Impact factor: 3.222
Authors: Jeffrey M Miller; Erin L Kinnally; R Todd Ogden; Maria A Oquendo; J John Mann; Ramin V Parsey Journal: Synapse Date: 2009-07 Impact factor: 2.562
Authors: Katherine L Gardner; Matthew W Hale; Stafford L Lightman; Paul M Plotsky; Christopher A Lowry Journal: Brain Res Date: 2009-09-23 Impact factor: 3.252
Authors: Swen Hesse; Philipp M Meyer; Karl Strecker; Henryk Barthel; Florian Wegner; Christian Oehlwein; Ioannis Ugo Isaias; Johannes Schwarz; Osama Sabri Journal: Eur J Nucl Med Mol Imaging Date: 2008-11-27 Impact factor: 9.236
Authors: Jay D Amsterdam; Andrew B Newberg; Cory F Newman; Justine Shults; Nancy Wintering; Irene Soeller Journal: J Neuroimaging Date: 2013-06-10 Impact factor: 2.486