Literature DB >> 1664365

[The central gray substance of the midbrain: the role of corticosteroids in the analgesic effect].

N I Iarushkina, A I Bogdanov, A A Filaretov.   

Abstract

The effect of stimulation of periaqueductal gray matter on pain threshold and blood corticosteroids was studied in anesthetized rats. The stimulation with 30-50-microA current resulted in an increase of analgesia and blood corticosteroids. An increase of current intensity up to 100 microA resulted in a decreasing corticosteroid level and analgetic effect. The magnitude and duration of the analgesia were decreased after blocking the pituitary-adrenocortical system. The corticosteroids seem to induce analgesia after stimulation of periaqueductal gray matter stimulation.

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Year:  1991        PMID： 1664365

Source DB:  PubMed          Journal:  Fiziol Zh SSSR Im I M Sechenova        ISSN： 0015-329X


  4 in total

1.  The relationship between analgesia and corticosteroid levels in rats.

Authors:  A I Bogdanov; N N Yarushkina
Journal:  Neurosci Behav Physiol       Date:  2000 Jul-Aug

Review 2.  The role of hypothalamo-hypophyseal-adrenocortical system hormones in controlling pain sensitivity.

Authors:  N I Yarushkina
Journal:  Neurosci Behav Physiol       Date:  2008-09-18

3.  Stress-induced analgesia. The role of hormones produced by the hypophyseal-adrenocortical system.

Authors:  A A Filaretov; A I Bogdanov; N I Yarushkina
Journal:  Neurosci Behav Physiol       Date:  1996 Nov-Dec

4.  Analgesic actions of corticotropin-releasing factor (CRF) on somatic pain sensitivity: involvement of glucocorticoid and CRF-2 receptors.

Authors:  N I Yarushkina; T R Bagaeva; L P Filaretova
Journal:  Neurosci Behav Physiol       Date:  2009-10-15
  4 in total

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