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Literature DB >> 1664332

JO1784, a novel sigma ligand, potentiates [3H]acetylcholine release from rat hippocampal slices.

J L Junien¹, F J Roman, G Brunelle, X Pascaud.

Abstract

JO1784, a potent and specific sigma ligand, potentiated the KCl-evoked release of [3H]acetylcholine (ACh) from rat hippocampal slices superfused in vitro at 10 and 30 microM. This effect was stereospecific and was antagonized by the presence of haloperidol (0.3 microM). Under similar conditions, (+)-SKF 10,047 also had a potentiating effect whereas di-o-tolyl-guanidine had an inhibitory effect. Phencyclidine was devoid of activity up to a concentration of 30 microM. These results show that sigma compounds display differential effects on evoked [3H]ACh release in rat hippocampal slice preparations.

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Year: 1991 PMID： 1664332 DOI： 10.1016/0014-2999(91)90593-f

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

11 in total

1. Sigma receptors [σRs]: biology in normal and diseased states.

Authors: Colin G Rousseaux; Stephanie F Greene
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2. Effects of sigma ligands on the cloned mu-, delta- and kappa-opioid receptors co-expressed with G-protein-activated K+ (GIRK) channel in Xenopus oocytes.

Authors: T Kobayashi; K Ikeda; T Ichikawa; S Togashi; T Kumanishi
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Review 3. Current hypotheses on sigma receptors and their physiological role: possible implications in psychiatry.

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Journal: J Psychiatry Neurosci Date: 1993-07 Impact factor: 6.186

Review 4. Roles of sigma-1 receptors in Alzheimer's disease.

Authors: Jia-Li Jin; Min Fang; Yan-Xin Zhao; Xue-Yuan Liu
Journal: Int J Clin Exp Med Date: 2015-04-15

5. The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice.

Authors: Maninder Malik; Claudia Rangel-Barajas; Nathalie Sumien; Chang Su; Meharvan Singh; Zhenglan Chen; Ren-Qi Huang; Johann Meunier; Tangui Maurice; Robert H Mach; Robert R Luedtke
Journal: Br J Pharmacol Date: 2015-04-10 Impact factor: 8.739

10. Stimulation of the sigma-1 receptor by DHEA enhances synaptic efficacy and neurogenesis in the hippocampal dentate gyrus of olfactory bulbectomized mice.

Authors: Shigeki Moriguchi; Yasuharu Shinoda; Yui Yamamoto; Yuzuru Sasaki; Kosuke Miyajima; Hideaki Tagashira; Kohji Fukunaga
Journal: PLoS One Date: 2013-04-08 Impact factor: 3.240

JO1784, a novel sigma ligand, potentiates [3H]acetylcholine release from rat hippocampal slices.

1. Sigma receptors [σRs]: biology in normal and diseased states.

2. Effects of sigma ligands on the cloned mu-, delta- and kappa-opioid receptors co-expressed with G-protein-activated K+ (GIRK) channel in Xenopus oocytes.

Review 3. Current hypotheses on sigma receptors and their physiological role: possible implications in psychiatry.

Review 4. Roles of sigma-1 receptors in Alzheimer's disease.

5. The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice.

6. Anti-amnesic effect of dimemorfan in mice.

7. Regional differences of the effect of sigma receptor ligands on the acetylcholine release in the rat brain.

8. Prevention of nimodipine-induced impairment of learning by the selective sigma ligand PRE-084.

9. A Role for Sigma Receptors in Stimulant Self Administration and Addiction.

10. Stimulation of the sigma-1 receptor by DHEA enhances synaptic efficacy and neurogenesis in the hippocampal dentate gyrus of olfactory bulbectomized mice.