BACKGROUND:Sevoflurane has become widely used in day surgery; however, desflurane may be a valuable alternative even in this setting. This study compares emergence from anaesthesia for day surgery with spontaneous breathing using either desflurane or sevoflurane. METHODS: This prospective, randomized, single-blinded study examined 70 ASA III patients undergoing elective ambulatory varicose vein surgery. Primary endpoint was emergence time (cessation of anaesthetic gas to communicating). Secondary endpoints included post-operative pain, nausea, time to discharge, and patient satisfaction. Patients were anaesthetized according to a standardized protocol including multimodal analgesia and antiemetic therapy and were randomized to receive sevoflurane or desflurane as the main anaesthetic while breathing spontaneously through a laryngeal mask airway. Fresh gas flow was oxygen in air 1 : 2 l/min. RESULTS: Intra-operative anaesthesia was uneventful apart from airway irritation observed in 5/35 desflurane and 1/35 sevoflurane patients. Emergence was 25-40% faster in patients anaesthetized with desflurane. Pain and post-operative nausea and vomiting (PONV) were equally infrequent in both groups. Overall, patient satisfaction was high with no difference between the groups. CONCLUSION:Desflurane is associated with a faster emergence with no differences during the post-operative course except a somewhat higher incidence of airway irritation.
RCT Entities:
BACKGROUND:Sevoflurane has become widely used in day surgery; however, desflurane may be a valuable alternative even in this setting. This study compares emergence from anaesthesia for day surgery with spontaneous breathing using either desflurane or sevoflurane. METHODS: This prospective, randomized, single-blinded study examined 70 ASA III patients undergoing elective ambulatory varicose vein surgery. Primary endpoint was emergence time (cessation of anaesthetic gas to communicating). Secondary endpoints included post-operative pain, nausea, time to discharge, and patient satisfaction. Patients were anaesthetized according to a standardized protocol including multimodal analgesia and antiemetic therapy and were randomized to receive sevoflurane or desflurane as the main anaesthetic while breathing spontaneously through a laryngeal mask airway. Fresh gas flow was oxygen in air 1 : 2 l/min. RESULTS: Intra-operative anaesthesia was uneventful apart from airway irritation observed in 5/35 desflurane and 1/35 sevofluranepatients. Emergence was 25-40% faster in patients anaesthetized with desflurane. Pain and post-operative nausea and vomiting (PONV) were equally infrequent in both groups. Overall, patient satisfaction was high with no difference between the groups. CONCLUSION:Desflurane is associated with a faster emergence with no differences during the post-operative course except a somewhat higher incidence of airway irritation.
Authors: Ana Stevanovic; Rolf Rossaint; Harald G Fritz; Gebhard Froeba; Joern Heine; Friedrich K Puehringer; Peter H Tonner; Mark Coburn Journal: Eur J Anaesthesiol Date: 2015-02 Impact factor: 4.330
Authors: Ana Kowark; Rolf Rossaint; Friedrich Pühringer; András P Keszei; Harald Fritz; Gebhard Fröba; Christopher Rex; Hansjörg Haas; Volker Otto; Mark Coburn Journal: Eur J Anaesthesiol Date: 2018-08 Impact factor: 4.330
Authors: Joseph G Werner; Karina Castellon-Larios; Cattleya Thongrong; Bodo E Knudsen; Deborah S Lowery; Maria A Antor; Sergio Daniel Bergese Journal: Front Med (Lausanne) Date: 2015-10-28