| Literature DB >> 16643019 |
Cailean Clarkson1, Dan Staerk, Steen Honoré Hansen, Peter J Smith, Jerzy W Jaroszewski.
Abstract
HPLC-SPE-NMR experiments with crude extracts of Harpagophytum procumbens allowed the rapid identification of novel, unstable chinane-type tricyclic diterpenes (1 and 2), along with numerous other constituents. Dramatic sensitivity gains achieved with this novel hyphenated technique establish a new paradigm in natural products research: rapid and rigorous structure determination of multiple extract components, including minor components, without preparative-scale isolation.Entities:
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Year: 2006 PMID： 16643019 DOI： 10.1021/np050504g
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050