| Literature DB >> 16642139 |
Marinko V Sarunic1, Seth Weinberg, Joseph A Izatt.
Abstract
We present a full-field phase microscopy technique for quantitative nanoscale surface profiling of samples in reflection. This technique utilizes swept-source optical coherence tomography in a full-field common path interferometer for phase-stable cross-sectional acquisition without scanning. Subwavelength variations in surface sample features are measured without interference from spurious reflections by processing the interferometric phase at a selected depth plane, providing a 1.3 nm stability for high signal-to-noise ratio surface features. Nanoscale imaging was demonstrated by measuring the location of receptor sites on a DNA assay biochip and the surface topography of erythrocytes in a blood smear.Mesh:
Year: 2006 PMID: 16642139 DOI: 10.1364/ol.31.001462
Source DB: PubMed Journal: Opt Lett ISSN: 0146-9592 Impact factor: 3.776