Literature DB >> 16641300

The Epstein-Barr virus BMRF1 gene is essential for lytic virus replication.

Bernhard Neuhierl1, Henri-Jacques Delecluse.   

Abstract

The Epstein-Barr virus (EBV) BMRF1 protein is a DNA polymerase processivity factor. We have deleted the BMRF1 open reading frame from the EBV genome and assessed the DeltaBMRF1 EBV phenotype. DeltaBMRF1 viruses were replication deficient, but the wild-type phenotype could be restored by BMRF1 trans-complementation. The replication-deficient phenotype included impaired lytic DNA replication and late protein expression. DeltaBMRF1 and wild-type viruses were undistinguishable in terms of their ability to transform primary B cells. Our results provide genetic evidence that BMRF1 is essential for lytic replication of the EBV genome.

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Year:  2006        PMID： 16641300      PMCID： PMC1472063          DOI： 10.1128/JVI.80.10.5078-5081.2006

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

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Authors:  P T Stukenberg; P S Studwell-Vaughan; M O'Donnell
Journal:  J Biol Chem       Date:  1991-06-15       Impact factor: 5.157

2.  Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis.

Authors:  C A Wu; N J Nelson; D J McGeoch; M D Challberg
Journal:  J Virol       Date:  1988-02       Impact factor: 5.103

3.  Architecture of replication compartments formed during Epstein-Barr virus lytic replication.

Authors:  Tohru Daikoku; Ayumi Kudoh; Masatoshi Fujita; Yutaka Sugaya; Hiroki Isomura; Noriko Shirata; Tatsuya Tsurumi
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

4.  Cooperation of EBV DNA polymerase and EA-D(BMRF1) in vitro and colocalization in nuclei of infected cells.

Authors:  A Kiehl; D I Dorsky
Journal:  Virology       Date:  1991-09       Impact factor: 3.616

5.  One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.

Authors:  K A Datsenko; B L Wanner
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

6.  Characteristics of a human cell line transformed by DNA from human adenovirus type 5.

Authors:  F L Graham; J Smiley; W C Russell; R Nairn
Journal:  J Gen Virol       Date:  1977-07       Impact factor: 3.891

7.  Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis.

Authors:  T Gardella; P Medveczky; T Sairenji; C Mulder
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

8.  Identification of polypeptide components of the Epstein-Barr virus early antigen complex with monoclonal antibodies.

Authors:  G R Pearson; B Vroman; B Chase; T Sculley; M Hummel; E Kieff
Journal:  J Virol       Date:  1983-07       Impact factor: 5.103

9.  Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.

Authors:  P A Johnson; M G Best; T Friedmann; D S Parris
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

10.  The regulated expression of Epstein-Barr virus. III. Proteins specified by EBV during the lytic cycle.

Authors:  G J Bayliss; H Wolf
Journal:  J Gen Virol       Date:  1981-09       Impact factor: 3.891
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  27 in total

1.  Tetrameric ring formation of Epstein-Barr virus polymerase processivity factor is crucial for viral replication.

Authors:  Sanae Nakayama; Takayuki Murata; Yoshihiro Yasui; Kazutaka Murayama; Hiroki Isomura; Teru Kanda; Tatsuya Tsurumi
Journal:  J Virol       Date:  2010-10-06       Impact factor: 5.103

2.  The Epstein-Barr virus alkaline exonuclease BGLF5 serves pleiotropic functions in virus replication.

Authors:  R Feederle; H Bannert; H Lips; N Müller-Lantzsch; H-J Delecluse
Journal:  J Virol       Date:  2009-03-04       Impact factor: 5.103

3.  Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells.

Authors:  Mark D Sides; Gregory J Block; Bin Shan; Kyle C Esteves; Zhen Lin; Erik K Flemington; Joseph A Lasky
Journal:  Virology       Date:  2011-05-24       Impact factor: 3.616

4.  The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD.

Authors:  Samuel G Salamun; Justine Sitz; Carlos F De La Cruz-Herrera; Jaime Yockteng-Melgar; Edyta Marcon; Jack Greenblatt; Amelie Fradet-Turcotte; Lori Frappier
Journal:  J Virol       Date:  2019-10-29       Impact factor: 5.103

5.  Validation of an Epstein-Barr Virus Antibody Risk Stratification Signature for Nasopharyngeal Carcinoma by Use of Multiplex Serology.

Authors:  Julia Simon; Zhiwei Liu; Allan Hildesheim; Tim Waterboer; Nicole Brenner; Kelly J Yu; Wan-Lun Hsu; Cheng-Ping Wang; Yin-Chu Chien; Anna E Coghill; Chien-Jen Chen; Julia Butt; Carla Proietti; Denise L Doolan
Journal:  J Clin Microbiol       Date:  2020-04-23       Impact factor: 5.948

6.  Mutant Cellular AP-1 Proteins Promote Expression of a Subset of Epstein-Barr Virus Late Genes in the Absence of Lytic Viral DNA Replication.

Authors:  Danielle E Lyons; Kuan-Ping Yu; Jason A Vander Heiden; Lee Heston; Dirk P Dittmer; Ayman El-Guindy; George Miller
Journal:  J Virol       Date:  2018-09-12       Impact factor: 5.103

7.  A Genome-Wide Epstein-Barr Virus Polyadenylation Map and Its Antisense RNA to EBNA.

Authors:  Vladimir Majerciak; Wenjing Yang; Jing Zheng; Jun Zhu; Zhi-Ming Zheng
Journal:  J Virol       Date:  2019-01-04       Impact factor: 5.103

Review 8.  An Epigenetic Journey: Epstein-Barr Virus Transcribes Chromatinized and Subsequently Unchromatinized Templates during Its Lytic Cycle.

Authors:  Adityarup Chakravorty; Bill Sugden; Eric C Johannsen
Journal:  J Virol       Date:  2019-04-03       Impact factor: 5.103

9.  Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication.

Authors:  Fu-Zhang Wang; Debasmita Roy; Edward Gershburg; Christopher B Whitehurst; Dirk P Dittmer; Joseph S Pagano
Journal:  J Virol       Date:  2009-09-16       Impact factor: 5.103

10.  Anti-TNFα therapy for inflammatory bowel diseases is associated with Epstein-Barr virus lytic activation.

Authors:  Sameer Lapsia; Siva Koganti; Salvatore Spadaro; Ramona Rajapakse; Anupama Chawla; Sumita Bhaduri-McIntosh
Journal:  J Med Virol       Date:  2015-08-31       Impact factor: 2.327
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