Oxidized lipids: the two faces of vascular inflammation.

Elevated plasma levels of low-density lipoprotein and generation of oxidized low-density lipoprotein have been directly associated with the pathogenesis of atherosclerosis, and lipid oxidation products have been directly linked with induction and propagation of monocytic subendothelial accumulation and other inflammatory reactions associated with chronic vascular inflammation. However, accumulating data suggest that oxidized lipids may also exhibit anti-inflammatory potential and serve as potent inhibitors of nuclear factor-kappaB-dependent proinflammatory cascade. In addition, we have characterized a group of bioactive components of oxidized phospholipids with barrier-protective effects towards endothelial cells in the models of agonist-induced endothelial permeability and lipopolysaccharide-induced lung dysfunction. This review discusses the role of oxidized lipids in the progression of atherosclerosis as well as the important anti-inflammatory effects of oxidized phospholipids and their potential role in the modulation of vascular barrier integrity.