BACKGROUND: Low CD4 cell counts predict HIV-related morbidity and mortality and may be associated with acute renal failure (ARF). OBJECTIVE: To estimate the effect of CD4 cell count on the incidence rate (IR) of ARF in ambulatory HIV-infected patients with access to highly active antiretroviral therapy. METHODS: Observational clinical cohort of HIV-infected patients recruited from a university-based infectious diseases clinic, between 2000 and 2002, and followed up until December 31, 2002. Poisson log-linear regression models were used to calculate ARF IRs, IR differences, and IR ratios. RESULTS: The mean age of the 705 study participants was 40 years, two thirds were male, and 61% were African American. Incidence rates of ARF were higher at lower CD4 cell counts and among patients who were coinfected with hepatitis C. Patients with hepatitis C coinfection who also had low CD4 cell counts had the highest adjusted IR of ARF. CONCLUSION: Immunosuppression and hepatitis C virus coinfection are associated with increased IRs of ARF in ambulatory HIV-1-infected patients.
BACKGROUND: Low CD4 cell counts predict HIV-related morbidity and mortality and may be associated with acute renal failure (ARF). OBJECTIVE: To estimate the effect of CD4 cell count on the incidence rate (IR) of ARF in ambulatory HIV-infectedpatients with access to highly active antiretroviral therapy. METHODS: Observational clinical cohort of HIV-infectedpatients recruited from a university-based infectious diseases clinic, between 2000 and 2002, and followed up until December 31, 2002. Poisson log-linear regression models were used to calculate ARF IRs, IR differences, and IR ratios. RESULTS: The mean age of the 705 study participants was 40 years, two thirds were male, and 61% were African American. Incidence rates of ARF were higher at lower CD4 cell counts and among patients who were coinfected with hepatitis C. Patients with hepatitis C coinfection who also had low CD4 cell counts had the highest adjusted IR of ARF. CONCLUSION: Immunosuppression and hepatitis C virus coinfection are associated with increased IRs of ARF in ambulatory HIV-1-infectedpatients.
Authors: G N Nadkarni; A Patel; P K Simoes; R Yacoub; N Annapureddy; S Kamat; I Konstantinidis; P Perumalswami; A Branch; S G Coca; C M Wyatt Journal: J Viral Hepat Date: 2015-07-20 Impact factor: 3.728
Authors: Roberto Minutolo; Alessio Aghemo; Antonio Chirianni; Fabrizio Fabrizi; Loreto Gesualdo; Edoardo G Giannini; Paolo Maggi; Vincenzo Montinaro; Ernesto Paoletti; Marcello Persico; Francesco Perticone; Salvatore Petta; Massimo Puoti; Giovanni Raimondo; Maria Rendina; Anna Linda Zignego Journal: Intern Emerg Med Date: 2018-09-25 Impact factor: 3.397
Authors: Robert C Kalayjian; Nora Franceschini; Samir K Gupta; Lynda A Szczech; Ezekiel Mupere; Ronald J Bosch; Marlene Smurzynski; Jeffrey M Albert Journal: AIDS Date: 2008-02-19 Impact factor: 4.177
Authors: Lloyd B Mulenga; Gina Kruse; Shabir Lakhi; Ronald A Cantrell; Stewart E Reid; Isaac Zulu; Elizabeth M Stringer; Zipporah Krishnasami; Alwyn Mwinga; Michael S Saag; Jeffrey S A Stringer; Benjamin H Chi Journal: AIDS Date: 2008-09-12 Impact factor: 4.177