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Literature DB >> 16639035

Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases.

Abstract

Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.

Entities: Chemical Species

Mesh：

Substances：
Reactive Oxygen Species

Year: 2006 PMID： 16639035 DOI： 10.1126/stke.3322006re3

Source DB: PubMed Journal: Sci STKE ISSN： 1525-8882

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Cited

33 in total

1. VDAC contributes to mRNA levels in Saccharomyces cerevisiae cells by the intracellular reduction/oxidation state dependent and independent mechanisms.

Authors: Hanna Gałgańska; Monika Antoniewicz; Małgorzata Budzińska; Lukasz Gałgański; Hanna Kmita
Journal: J Bioenerg Biomembr Date: 2010-11-12 Impact factor: 2.945

2. Reduced extracellular phagocyte oxidative activity, antioxidant level changes and increased oxidative damage in healthy human blood as a function of age.

Authors: Margarita L Alexandrova; Petyo G Bochev
Journal: Age (Dordr) Date: 2009-01-24

3. Magnetic levitation of single cells.

Authors: Naside Gozde Durmus; H Cumhur Tekin; Sinan Guven; Kaushik Sridhar; Ahu Arslan Yildiz; Gizem Calibasi; Ionita Ghiran; Ronald W Davis; Lars M Steinmetz; Utkan Demirci
Journal: Proc Natl Acad Sci U S A Date: 2015-06-29 Impact factor: 11.205

4. Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy.

Authors: Subash C Gupta; David Hevia; Sridevi Patchva; Byoungduck Park; Wonil Koh; Bharat B Aggarwal
Journal: Antioxid Redox Signal Date: 2012-01-16 Impact factor: 8.401

9. Secretion expression of SOD1 and its overlapping function with GSH in brewing yeast strain for better flavor and anti-aging ability.

Authors: Zhaoyue Wang; Xuejing Bai; Xiuping He; Borun Zhang
Journal: J Ind Microbiol Biotechnol Date: 2014-07-19 Impact factor: 3.346

10. Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-kappaB signalling pathways in human pancreatic adenocarcinoma cells.

Authors: S T Lau; Z X Lin; P S Leung
Journal: Br J Cancer Date: 2010-01-12 Impact factor: 7.640

Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases.

1. VDAC contributes to mRNA levels in Saccharomyces cerevisiae cells by the intracellular reduction/oxidation state dependent and independent mechanisms.

2. Reduced extracellular phagocyte oxidative activity, antioxidant level changes and increased oxidative damage in healthy human blood as a function of age.

3. Magnetic levitation of single cells.

4. Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy.

5. The protective effect of α-Lipoic acid on mitochondria in the kidney of diabetic rats.

6. A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.

Review 7. The energy-redox axis in aging and age-related neurodegeneration.

8. The TOM complex is involved in the release of superoxide anion from mitochondria.

9. Secretion expression of SOD1 and its overlapping function with GSH in brewing yeast strain for better flavor and anti-aging ability.

10. Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-kappaB signalling pathways in human pancreatic adenocarcinoma cells.