Literature DB >> 16638580

Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF-alpha mRNA expression in human monocytes by allicin.

Nazarul Hasan1, Nabiha Yusuf, Zahra Toossi, Najmul Islam.   

Abstract

Chronic inflammation associated with tumor necrosis factor (TNF)-alpha and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF-alpha. We show the augmented expression of TNF-alpha mRNA in MTB-infected monocytes by cellular activation and ROS was suppressed by allicin in a dose-dependent manner. Also, allicin enhanced the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF-alpha in MTB-infected monocytes. Hence, allicin may prove to be a valuable natural antioxidant in combating tuberculosis.

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Year:  2006        PMID： 16638580     DOI： 10.1016/j.febslet.2006.03.071

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

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4.  The promises and limitations of N-acetylcysteine as a potentiator of first-line and second-line tuberculosis drugs.

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7.  Effects of allicin supplementation on plasma markers of exercise-induced muscle damage, IL-6 and antioxidant capacity.

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Review 8.  The effect of nutraceuticals on multiple signaling pathways in cardiac fibrosis injury and repair.

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9.  Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection.

Authors:  Yonghui Feng; Xiaotong Zhu; Qinghui Wang; Yongjun Jiang; Hong Shang; Liwang Cui; Yaming Cao
Journal:  Malar J       Date:  2012-08-08       Impact factor: 2.979

10.  Correlation between bone mineral density and oxidative stress in postmenopausal women.

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