OBJECTIVE: The study examined to what degree schizophrenia is characterized by a neuropsychological (NP) test profile specific in shape and level compared with depression and normal functioning. METHOD: Fifty-three patients with schizophrenia, 45 with non-psychotic depression, and 50 normals were assessed with a comprehensive NP test battery and clinical instruments. NP test scores were factor analyzed into seven composite scores. RESULTS: Schizophrenia patients performed significantly below normals across all seven composite scores, whereas depression patients were impaired in two. Verbal memory was most impaired. Sixty-two percent of schizophrenia patients were moderately or severely impaired, the corresponding figure for depression was 28%. Impairment was moderately associated with IQ level and clinical symptom load in schizophrenia, but not in depression. CONCLUSION: Schizophrenia is characterized by deficits across a wide range of NP functions. Thirty-eight percent of the patients are within normal limits. A mild and limited NP disturbance is apparent in depression.
OBJECTIVE: The study examined to what degree schizophrenia is characterized by a neuropsychological (NP) test profile specific in shape and level compared with depression and normal functioning. METHOD: Fifty-three patients with schizophrenia, 45 with non-psychotic depression, and 50 normals were assessed with a comprehensive NP test battery and clinical instruments. NP test scores were factor analyzed into seven composite scores. RESULTS:Schizophreniapatients performed significantly below normals across all seven composite scores, whereas depressionpatients were impaired in two. Verbal memory was most impaired. Sixty-two percent of schizophreniapatients were moderately or severely impaired, the corresponding figure for depression was 28%. Impairment was moderately associated with IQ level and clinical symptom load in schizophrenia, but not in depression. CONCLUSION:Schizophrenia is characterized by deficits across a wide range of NP functions. Thirty-eight percent of the patients are within normal limits. A mild and limited NP disturbance is apparent in depression.
Authors: Krista M Wisner; Brita Elvevåg; James M Gold; Daniel R Weinberger; Dwight Dickinson Journal: Schizophr Res Date: 2010-10-28 Impact factor: 4.939
Authors: Amy T Peters; Rachel H Jacobs; Natania A Crane; Kelly A Ryan; Sara L Weisenbach; Olusola Ajilore; Melissa Lamar; Michelle T Kassel; Laura B Gabriel; Amy E West; Jon-Kar Zubieta; Scott A Langenecker Journal: Early Interv Psychiatry Date: 2015-07-14 Impact factor: 2.732
Authors: Kelly A Ryan; Shervin Assari; Kaley Angers; David F Marshall; Kristin Hinrichs; Rebecca Easter; Pallavi Babu; Bethany D Pester; Scott A Langenecker; Melvin G McInnis Journal: Bipolar Disord Date: 2017-09-14 Impact factor: 6.744
Authors: Bruce E Wexler; Hongtu Zhu; Morris D Bell; Sarah S Nicholls; Robert K Fulbright; John C Gore; Tiziano Colibazzi; Jose Amat; Ravi Bansal; Bradley S Peterson Journal: Am J Psychiatry Date: 2008-09-02 Impact factor: 18.112