OBJECTIVE: This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia. METHOD: Using 134 family trios with a history of psychosis, we genotyped six of the seven markers originally identified to be associated with schizophrenia in Iceland. RESULTS: The neuregulin Icelandic haplotype was not associated with schizophrenia in the CVCR population. However, a novel haplotype was found to be overrepresented in subjects with functional psychosis (global P-value > 0.05). Stratification of the sample by history of mania suggests that this haplotype may be preferentially over-transmitted to persons with a history of manic psychosis. CONCLUSION: These results suggest that the neuregulin 1 gene is unlikely to play a major role in predisposing to schizophrenia in the CVCR. Further studies in the CVCR and other Latin American populations should be performed in order to corroborate these findings.
OBJECTIVE: This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia. METHOD: Using 134 family trios with a history of psychosis, we genotyped six of the seven markers originally identified to be associated with schizophrenia in Iceland. RESULTS: The neuregulin Icelandic haplotype was not associated with schizophrenia in the CVCR population. However, a novel haplotype was found to be overrepresented in subjects with functional psychosis (global P-value > 0.05). Stratification of the sample by history of mania suggests that this haplotype may be preferentially over-transmitted to persons with a history of manic psychosis. CONCLUSION: These results suggest that the neuregulin 1 gene is unlikely to play a major role in predisposing to schizophrenia in the CVCR. Further studies in the CVCR and other Latin American populations should be performed in order to corroborate these findings.
Authors: Kristin K Nicodemus; Amanda J Law; Eugenia Radulescu; Augustin Luna; Bhaskar Kolachana; Radhakrishna Vakkalanka; Dan Rujescu; Ina Giegling; Richard E Straub; Kate McGee; Bert Gold; Michael Dean; Pierandrea Muglia; Joseph H Callicott; Hao-Yang Tan; Daniel R Weinberger Journal: Arch Gen Psychiatry Date: 2010-10
Authors: Daniel Fleck; Matthias Voss; Ben Brankatschk; Camilla Giudici; Heike Hampel; Benjamin Schwenk; Dieter Edbauer; Akio Fukumori; Harald Steiner; Elisabeth Kremmer; Martina Haug-Kröper; Moritz J Rossner; Regina Fluhrer; Michael Willem; Christian Haass Journal: J Biol Chem Date: 2015-11-16 Impact factor: 5.157
Authors: Daphne Voineskos; Vincenzo De Luca; Stuart Macgregor; Olga Likhodi; Laura Miller; Aristotle N Voineskos; James L Kennedy Journal: J Neural Transm (Vienna) Date: 2009-01-28 Impact factor: 3.575
Authors: Fernando S Goes; Virginia L Willour; Peter P Zandi; Pamela L Belmonte; Dean F MacKinnon; Francis M Mondimore; Barbara Schweizer; Elliot S Gershon; Francis J McMahon; James B Potash Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2009-07-05 Impact factor: 3.568