Literature DB >> 16637882

Subcellular localization of epidermal growth factor receptor in human submandibular gland.

M S Lantini1, M Cossu, M Isola, M Piras, M Piludu.   

Abstract

The subcellular distribution of the epidermal growth factor receptor (EGFr) was demonstrated in the normal human submandibular gland by means of immunogold cytochemistry. EGFr labelling appeared in both acinar and ductal cells, where strong immunoreactivity was associated with a tubulovesicular system near the basolateral surfaces. In addition, groups of reactive vesicles were highlighted among secretory granules of both serous and mucous cells and at the apex of ductal cells. Basolateral vesicles were interpreted as being a result of EGFr internalization after activation by an exogenous ligand, although the functional meaning of those located apically remains unclear.

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Year:  2006        PMID： 16637882      PMCID： PMC2100223          DOI： 10.1111/j.1469-7580.2006.00568.x

Source DB:  PubMed          Journal:  J Anat        ISSN： 0021-8782            Impact factor:   2.610


  31 in total

1.  Pathobiology of salivary glands. IV. Histogenetic concepts and cycling cells in human parotid and submandibular glands cultured in floating collagen gels.

Authors:  I Dardick; A M Dardick; A J MacKay; G C Pastolero; P J Gullane; A P Burford-Mason
Journal:  Oral Surg Oral Med Oral Pathol       Date:  1993-09

Review 2.  Secretion by striated ducts of mammalian major salivary glands: review from an ultrastructural, functional, and evolutionary perspective.

Authors:  B Tandler; E W Gresik; T Nagato; C J Phillips
Journal:  Anat Rec       Date:  2001-10-01

3.  Cytochemical localization of ouabain-sensitive, K+ -dependent p-nitrophenylphosphatase and Ca++-stimulated adenosine triphosphatase activities in human parotid and submandibular glands.

Authors:  M Cossu; M S Lantini; P Puxeddu; A Riva
Journal:  Histochemistry       Date:  1984

4.  Synthesis of secretory and plasma membrane glycoproteins by striated duct cells of rat salivary glands as visualized by radioautography after 3H-fucose injection.

Authors:  A R Hand
Journal:  Anat Rec       Date:  1979-10

5.  Immunohistochemical expression of epidermal growth factor receptor in salivary gland tumours.

Authors:  K Yamada; K Iwai; Y Okada; M Mori
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1989

6.  Immunohistochemical localization of the epidermal growth factor receptor in normal human tissues.

Authors:  I Damjanov; B Mildner; B B Knowles
Journal:  Lab Invest       Date:  1986-11       Impact factor: 5.662

7.  Ultrastructural localization of epidermal growth factor receptor in human parotid gland.

Authors:  M Piludu; M S Lantini; M Isola; F Lecca; M Cossu
Journal:  Eur J Morphol       Date:  2002-10

8.  Cellular localisation of human epidermal growth factor receptor.

Authors:  B Gusterson; G Cowley; J A Smith; B Ozanne
Journal:  Cell Biol Int Rep       Date:  1984-08

9.  Epidermal growth factor (EGF) expression in human salivary glands. An immunohistochemical study.

Authors:  B Dubiel; B Mytar; A Tarnawski; M Zembala; J Stachura
Journal:  J Physiol Pharmacol       Date:  1992-03       Impact factor: 3.011

Review 10.  Role of epidermal growth factor receptor activation in regulating mucin synthesis.

Authors:  J A Nadel
Journal:  Respir Res       Date:  2001-02-21
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  2 in total

1.  Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands.

Authors:  Stephanie J Byer; Nicole M Brossier; Lafe T Peavler; Jenell M Eckert; Stacey Watkins; Kevin A Roth; Steven L Carroll
Journal:  J Neuropathol Exp Neurol       Date:  2013-03       Impact factor: 3.685

2.  Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.

Authors:  Yong Fu; Zobeida Cruz-Monserrate; H Helen Lin; Yiyin Chung; Baoan Ji; Szu-Min Lin; Steven Vonderfecht; Craig D Logsdon; Chien-Feng Li; David K Ann
Journal:  Sci Rep       Date:  2015-08-20       Impact factor: 4.379
  2 in total

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