Literature DB >> 166378

Involvement of nicotinamide adenine dinucleotide in the action of cholera toxin in vitro.

D M Gill.   

Abstract

NAD is a necessary cofactor for the activation of adenylate cyclase (ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1) by cholera toxin. Lysates of certain types of cell that hydrolyze their endogenous store of NAD after cell disruption respond poorly or not at all to cholera toxin. Lysates of pigeon erythrocytes, which lack enzymes that degrade NAD, provide a convenient and reproducible system for assaying the activity of cholera toxin in vitro and allow investigation of the mechanism of action of the toxin upon broken cells.

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Year:  1975        PMID： 166378      PMCID： PMC432694          DOI： 10.1073/pnas.72.6.2064

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  4 in total

1.  [DPN- and TPN-specific nucleosidases in erythrocytes].

Authors:  E C HOFMANN; S RAPOPORT
Journal:  Biochim Biophys Acta       Date:  1955-10

2.  Poly (adenosine diphosphate ribose) synthesis in soluble extracts of animal organs.

Authors:  D M Gill
Journal:  J Biol Chem       Date:  1972-09-25       Impact factor: 5.157

3.  Determination of subpicomole levels of NADH and FMN using bacterial luciferase and the liquid scintillation spectrometer.

Authors:  P E Stanley
Journal:  Anal Biochem       Date:  1971-02       Impact factor: 3.365

4.  Studies on the mode of action of diphtheria toxin. IV. Specificity of the cofactor (NAD) requirement for toxin action in cell-free systems.

Authors:  R S Goor; A M Pappenheimer
Journal:  J Exp Med       Date:  1967-11-01       Impact factor: 14.307
  4 in total
  37 in total

1.  ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

Authors:  D M Gill; R Meren
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

2.  Studies on the time course and rate-limiting steps in the activation of adenylate cyclase in rat liver by cholera toxin.

Authors:  J Fischer; T R Kohler; L G Lipson; J Flores; P A Witkum; G W Sharp
Journal:  Biochem J       Date:  1978-07-01       Impact factor: 3.857

3.  Stimulation of epinephrine-sensitive fat cell adenylate cyclase by cytosol: effect of cholera toxin.

Authors:  U Ganguly; W B Greenough
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

4.  The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding.

Authors:  Lutz Birnbaumer
Journal:  Biochim Biophys Acta       Date:  2006-10-04

5.  Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness.

Authors:  J Moss; P H Fishman; V C Manganiello; M Vaughan; R O Brady
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

6.  Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes.

Authors:  B R Mullin; S M Aloj; P H Fishman; G Lee; L D Kohn; R O Brady
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

7.  Activation of adenylate cyclase by heat-labile Escherichia coli enterotoxin. Evidence for ADP-ribosyltransferase activity similar to that of choleragen.

Authors:  J Moss; S H Richardson
Journal:  J Clin Invest       Date:  1978-08       Impact factor: 14.808

8.  Activation by cholera toxin of adenylate cyclase solubilized from rat liver.

Authors:  S Heyningen
Journal:  Biochem J       Date:  1976-09-01       Impact factor: 3.857

9.  Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system.

Authors:  D Cassel; T Pfeuffer
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

10.  Exohemagglutinins: new products of vibrios.

Authors:  K Oishi; S Yokoshima; T Tomiyama; K Aida
Journal:  Appl Environ Microbiol       Date:  1979-07       Impact factor: 4.792
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