Literature DB >> 16637601

Identification of sugar isomers by single-molecule force spectroscopy.

Qingmin Zhang1, Piotr E Marszalek.   

Abstract

The nanomechanical properties of beta-galactan, a 1 --> 4 linked beta-d-galactose polysaccharide, were investigated with AFM-based single-molecule force spectroscopy. AFM captured a unique plateau at 640 pN in the force spectrogram of beta-galactan, which is significantly different than the plateau at 280 pN in the force spectrogram of amylose. Thus, our results demonstrate that force spectroscopy is able to discriminate between sugar isomers in which axial and equatorial bonds at C1 and C4 are swapped.

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Year:  2006        PMID: 16637601     DOI: 10.1021/ja058828e

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  3 in total

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2.  Modification of a single-molecule AFM probe with highly defined surface functionality.

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3.  Purification, Preliminary Structure and Antitumor Activity of Exopolysaccharide Produced by Streptococcus thermophilus CH9.

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  3 in total

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