BACKGROUND: Hereditary spastic paraplegia (HSP) are classified clinically as pure when progressive spasticity occurs in isolation or complicated when other neurologic abnormalities are present. At least 22 genetic loci have been linked to HSP, 8 of which are autosomal recessive (ARHSP). HSP complicated with the presence of thin corpus callosum (HSP-TCC) is a common subtype of HSP. One genetic locus has been identified on chromosome 15q13-q15 (SPG11) for HSP-TCC, but some HSP-TCC families have not been linked to this locus. METHODS: The authors characterized two families clinically and radiologically and performed a genome-wide scan and linkage analysis. RESULTS: The two families had complicated ARHSP. The affected individuals in Family A had thin corpus callosum and mental retardation, whereas in Family B two of three affected individuals had epilepsy. In both families linkage analysis identified a locus on chromosome 8 between markers D8S1820 and D8S532 with the highest combined lod score of 7.077 at marker D8S505. This 9 cM interval located on 8p12-p11.21 represents a new locus for ARHSP-TCC. Neuregulin and KIF13B genes, located within this interval, are interesting functional candidate genes for this HSP form. CONCLUSION: Two consanguineous families with complicated autosomal recessive hereditary spastic paraplegia were clinically characterized and genetically mapped to a new locus on 8p12-p11.21.
BACKGROUND:Hereditary spastic paraplegia (HSP) are classified clinically as pure when progressive spasticity occurs in isolation or complicated when other neurologic abnormalities are present. At least 22 genetic loci have been linked to HSP, 8 of which are autosomal recessive (ARHSP). HSP complicated with the presence of thin corpus callosum (HSP-TCC) is a common subtype of HSP. One genetic locus has been identified on chromosome 15q13-q15 (SPG11) for HSP-TCC, but some HSP-TCC families have not been linked to this locus. METHODS: The authors characterized two families clinically and radiologically and performed a genome-wide scan and linkage analysis. RESULTS: The two families had complicated ARHSP. The affected individuals in Family A had thin corpus callosum and mental retardation, whereas in Family B two of three affected individuals had epilepsy. In both families linkage analysis identified a locus on chromosome 8 between markers D8S1820 and D8S532 with the highest combined lod score of 7.077 at marker D8S505. This 9 cM interval located on 8p12-p11.21 represents a new locus for ARHSP-TCC. Neuregulin and KIF13B genes, located within this interval, are interesting functional candidate genes for this HSP form. CONCLUSION: Two consanguineous families with complicated autosomal recessive hereditary spastic paraplegia were clinically characterized and genetically mapped to a new locus on 8p12-p11.21.
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Authors: Laura Southgate; Dimitra Dafou; Jacqueline Hoyle; Nan Li; Esther Kinning; Peter Critchley; Andrea H Németh; Kevin Talbot; Parayil S Bindu; Sanjib Sinha; Arun B Taly; Seetharam Raghavendra; Ferenc Müller; Eamonn R Maher; Richard C Trembath Journal: Neurogenetics Date: 2010-10 Impact factor: 2.660
Authors: Roshan Koul; Fathiya M Al-Murshedi; Faisal M Al-Azri; Ranjit Mani; Rana A Abdelrahim; Vivek Koul; Amna M Alfutaisi Journal: Sultan Qaboos Univ Med J Date: 2013-06-25
Authors: Janneke H M Schuurs-Hoeijmakers; Michael T Geraghty; Erik-Jan Kamsteeg; Salma Ben-Salem; Susanne T de Bot; Bonnie Nijhof; Ilse I G M van de Vondervoort; Marinette van der Graaf; Anna Castells Nobau; Irene Otte-Höller; Sascha Vermeer; Amanda C Smith; Peter Humphreys; Jeremy Schwartzentruber; Bassam R Ali; Saeed A Al-Yahyaee; Said Tariq; Thachillath Pramathan; Riad Bayoumi; Hubertus P H Kremer; Bart P van de Warrenburg; Willem M R van den Akker; Christian Gilissen; Joris A Veltman; Irene M Janssen; Anneke T Vulto-van Silfhout; Saskia van der Velde-Visser; Dirk J Lefeber; Adinda Diekstra; Corrie E Erasmus; Michèl A Willemsen; Lisenka E L M Vissers; Martin Lammens; Hans van Bokhoven; Han G Brunner; Ron A Wevers; Annette Schenck; Lihadh Al-Gazali; Bert B A de Vries; Arjan P M de Brouwer Journal: Am J Hum Genet Date: 2012-11-21 Impact factor: 11.025