OBJECTIVE: The UK Collaborative ECMO trial provided an opportunity to describe mortality and morbidity associated with a neonatal ECMO policy compared with conventional management. The improved survival in the ECMO group was not offset by an increase in disability at 4 years, but the children were too young to assess educational and other longer-term impacts. The objective of this study was to assess the longer-term impact of these policies at age 7 years. METHODS: A psychologist assessed 90 of the 100 children available for follow-up without prior knowledge of treatment allocation. The assessments took place at the children's schools within 3 months of their 7th birthdays. RESULTS:Sixty-eight of 89 (76%) children recorded a cognitive level within the normal range. Learning problems were similar in the 2 groups, and there were notable difficulties with spatial and processing tasks. A higher respiratory morbidity and increased risk of behavioral problems among children treated conventionally persisted. Progressive sensorineural hearing loss was found in both groups. CONCLUSIONS: The underlying disease processes appear to be the major influence on morbidity at 7 years. The beneficial influence of an ECMO policy is still present at 7 years.
RCT Entities:
OBJECTIVE: The UK Collaborative ECMO trial provided an opportunity to describe mortality and morbidity associated with a neonatal ECMO policy compared with conventional management. The improved survival in the ECMO group was not offset by an increase in disability at 4 years, but the children were too young to assess educational and other longer-term impacts. The objective of this study was to assess the longer-term impact of these policies at age 7 years. METHODS: A psychologist assessed 90 of the 100 children available for follow-up without prior knowledge of treatment allocation. The assessments took place at the children's schools within 3 months of their 7th birthdays. RESULTS: Sixty-eight of 89 (76%) children recorded a cognitive level within the normal range. Learning problems were similar in the 2 groups, and there were notable difficulties with spatial and processing tasks. A higher respiratory morbidity and increased risk of behavioral problems among children treated conventionally persisted. Progressive sensorineural hearing loss was found in both groups. CONCLUSIONS: The underlying disease processes appear to be the major influence on morbidity at 7 years. The beneficial influence of an ECMO policy is still present at 7 years.
Authors: Andrew D Meyer; Andrew A Wiles; Oswaldo Rivera; Edward C Wong; Robert J Freishtat; Khoydar Rais-Bahrami; Heidi J Dalton Journal: Pediatr Crit Care Med Date: 2012-07 Impact factor: 3.624
Authors: Marlous J Madderom; Jolanda J C M Reuser; Elisabeth M W J Utens; Joost van Rosmalen; Marlou Raets; Paul Govaert; Katerina Steiner; Saskia J Gischler; Dick Tibboel; Arno F J van Heijst; Hanneke Ijsselstijn Journal: Intensive Care Med Date: 2013-06-06 Impact factor: 17.440
Authors: Jennifer R Benjamin; Kathryn E Gustafson; P Brian Smith; Kirsten M Ellingsen; K Brooke Tompkins; Ronald N Goldberg; C Michael Cotten; Ricki F Goldstein Journal: J Pediatr Surg Date: 2013-04 Impact factor: 2.545
Authors: L van den Hout; I Sluiter; S Gischler; A De Klein; R Rottier; H Ijsselstijn; I Reiss; D Tibboel Journal: Pediatr Surg Int Date: 2009-09 Impact factor: 1.827