Mustafa Akçam1, Aygen Yilmaz. 1. Department of Pediatrics, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
Abstract
BACKGROUND: Safe and effective treatment of infantile colic (IC) has not yet been determined. In this study, the authors aimed to investigate the efficiency of 30% glucose solution in the treatment of IC. METHODS: A total of 25 infants diagnosed as typical IC were given 1 mL of 30% glucose solution or sterile water for 4 days consecutively, in a randomized, double blind crossover trial. The effect was measured by parents' scoring. RESULTS: Parents reported varying degrees of improvement in 16 infants (64%) given glucose solution, and in 12 infants (48%) given placebo. Comparison of treatment modalities were statistically significant (P = 0.031). There was no side-effect during treatments. CONCLUSION: The present study revealed that 30% glucose was effective in the treatment of IC. Since oral glucose solution is natural, safe, cheap and easily achievable, it might be considered as an alternative therapy.
RCT Entities:
BACKGROUND: Safe and effective treatment of infantile colic (IC) has not yet been determined. In this study, the authors aimed to investigate the efficiency of 30% glucose solution in the treatment of IC. METHODS: A total of 25 infants diagnosed as typical IC were given 1 mL of 30% glucose solution or sterile water for 4 days consecutively, in a randomized, double blind crossover trial. The effect was measured by parents' scoring. RESULTS: Parents reported varying degrees of improvement in 16 infants (64%) given glucose solution, and in 12 infants (48%) given placebo. Comparison of treatment modalities were statistically significant (P = 0.031). There was no side-effect during treatments. CONCLUSION: The present study revealed that 30% glucose was effective in the treatment of IC. Since oral glucose solution is natural, safe, cheap and easily achievable, it might be considered as an alternative therapy.
Authors: James Mahon; Carlos Lifschitz; Thomas Ludwig; Nikhil Thapar; Julie Glanville; Mohamad Miqdady; Miguel Saps; Seng Hock Quak; Irene Lenoir Wijnkoop; Mary Edwards; Hannah Wood; Hania Szajewska Journal: BMJ Open Date: 2017-11-14 Impact factor: 2.692