Literature DB >> 1663495

Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

A Copani1, G Raciti, V Bruno, M A Sortino, F Nicoletti, P L Canonico, A Cambria.   

Abstract

Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

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Year:  1991        PMID： 1663495

Source DB:  PubMed          Journal:  Ital J Biochem        ISSN： 0021-2938


  3 in total

1.  Plasticity of cholinoreceptors of neurons of the common snail after effects on inositol-1,4,5-triphosphate- and CA(2+)-dependant mobilization of stored CA2+ and the level of phosphatidic acid.

Authors:  A S Pivovarov
Journal:  Neurosci Behav Physiol       Date:  1995 Nov-Dec

2.  Inositol hexakisphosphate binding sites in rat heart and brain.

Authors:  K G Rowley; A L Gundlach; M Cincotta; W J Louis
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

3.  Molecular mechanism of inositol hexaphosphate-mediated apoptosis in human malignant glioblastoma T98G cells.

Authors:  Surajit Karmakar; Naren L Banik; Swapan K Ray
Journal:  Neurochem Res       Date:  2007-07-07       Impact factor: 3.996
  3 in total

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