BACKGROUND: Moderate hyperhomocysteinemia and B vitamins deficiency are thought to be risk factors for venous thromboembolism (VTE). The causality and independence of those associations are still questioned. METHODS: We measured fasting serum total homocysteine, folates, and vitamin B12 levels as well as 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotypes in 467 patients hospitalized with a first well-documented deep vein thrombosis and/or pulmonary embolism not related to a major acquired risk factor and 467 controls matched for gender and age. RESULTS: Mild hyperhomocysteinemia, low serum folates, and vitamin B12 were associated with VTE independently of each other. In multivariate analysis, odds ratios (OR) (95% CI) for VTE associated with mild hyperhomocysteinemia (>15 micromol L(-1)), low serum folates (< or = 4.9 nmol L(-1)), and vitamin B12 (< or = 253 pmol L(-1)) were 1.48 (1.05-2.08), 3.14 (1.35-7.32) and 1.42 (1.03-1.98), respectively. An MTHFRC677T genotype was not significantly associated with VTE; OR (95% CI): 1.13 (0.70-1.81) CONCLUSIONS: The current data provides further knowledge in the complex relationship between hyperhomocysteinemia, low vitamin levels, and VTE.
BACKGROUND: Moderate hyperhomocysteinemia and B vitamins deficiency are thought to be risk factors for venous thromboembolism (VTE). The causality and independence of those associations are still questioned. METHODS: We measured fasting serum total homocysteine, folates, and vitamin B12 levels as well as 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotypes in 467 patients hospitalized with a first well-documented deep vein thrombosis and/or pulmonary embolism not related to a major acquired risk factor and 467 controls matched for gender and age. RESULTS: Mild hyperhomocysteinemia, low serum folates, and vitamin B12 were associated with VTE independently of each other. In multivariate analysis, odds ratios (OR) (95% CI) for VTE associated with mild hyperhomocysteinemia (>15 micromol L(-1)), low serum folates (< or = 4.9 nmol L(-1)), and vitamin B12 (< or = 253 pmol L(-1)) were 1.48 (1.05-2.08), 3.14 (1.35-7.32) and 1.42 (1.03-1.98), respectively. An MTHFRC677T genotype was not significantly associated with VTE; OR (95% CI): 1.13 (0.70-1.81) CONCLUSIONS: The current data provides further knowledge in the complex relationship between hyperhomocysteinemia, low vitamin levels, and VTE.
Authors: D A Trégouët; A Delluc; A Roche; C Derbois; R Olaso; M Germain; M de Andrade; W Tang; D I Chasman; A van Hylckama Vlieg; P H Reitsma; C Kabrhel; N Smith; P E Morange Journal: J Thromb Haemost Date: 2016-08-06 Impact factor: 5.824
Authors: Angel F Remacha; Joan Carles Souto; José Luis Piñana; María Pilar Sardà; Josep Maria Queraltó; Joan Martí-Fabregas; Xavier García-Moll; Cristina Férnandez; Alvaro Rodriguez; Jorge Cuesta Journal: Int J Hematol Date: 2011-04-08 Impact factor: 2.490
Authors: Marine Germain; Daniel I Chasman; Hugoline de Haan; Weihong Tang; Sara Lindström; Lu-Chen Weng; Mariza de Andrade; Marieke C H de Visser; Kerri L Wiggins; Pierre Suchon; Noémie Saut; David M Smadja; Grégoire Le Gal; Astrid van Hylckama Vlieg; Antonio Di Narzo; Ke Hao; Christopher P Nelson; Ares Rocanin-Arjo; Lasse Folkersen; Ramin Monajemi; Lynda M Rose; Jennifer A Brody; Eline Slagboom; Dylan Aïssi; France Gagnon; Jean-Francois Deleuze; Panos Deloukas; Christophe Tzourio; Jean-Francois Dartigues; Claudine Berr; Kent D Taylor; Mete Civelek; Per Eriksson; Bruce M Psaty; Jeanine Houwing-Duitermaat; Alison H Goodall; François Cambien; Peter Kraft; Philippe Amouyel; Nilesh J Samani; Saonli Basu; Paul M Ridker; Frits R Rosendaal; Christopher Kabrhel; Aaron R Folsom; John Heit; Pieter H Reitsma; David-Alexandre Trégouët; Nicholas L Smith; Pierre-Emmanuel Morange Journal: Am J Hum Genet Date: 2015-03-12 Impact factor: 11.025
Authors: Francesco Paciullo; Paola Santina Menduno; Davide Tucci; Anna Caricato; Carlo Cagini; Paolo Gresele Journal: Intern Emerg Med Date: 2022-01-14 Impact factor: 5.472
Authors: James Douketis; Alberto Tosetto; Maura Marcucci; Trevor Baglin; Benilde Cosmi; Mary Cushman; Paul Kyrle; Daniela Poli; R Campbell Tait; Alfonso Iorio Journal: BMJ Date: 2011-02-24