Literature DB >> 16634709

Sex hormones: a role in the control of multiple sclerosis?

Valentina Tomassini1, Carlo Pozzilli.   

Abstract

Several lines of evidence suggest that gender affects the susceptibility and course of multiple sclerosis. A higher disease prevalence, as well as an overall better prognosis, in women than men is observed. This sex dimorphism may be explained by the effect of sex hormones on brain damage and repair mechanisms. Experimental, clinical and MRI evidence confirms a pathogenetic link between sex hormones and multiple sclerosis, also suggesting sex-specific effects of hormones in multiple sclerosis pathology and therapy. A gender-based approach to multiple sclerosis could provide further benefits for its treatment and management.

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Year:  2006        PMID： 16634709     DOI： 10.1517/14656566.7.7.857

Source DB:  PubMed          Journal:  Expert Opin Pharmacother        ISSN： 1465-6566            Impact factor:   3.889


  9 in total

1.  Multimodal analysis in acute and chronic experimental autoimmune encephalomyelitis.

Authors:  Silvia Giatti; Mariaserena Boraso; Federico Abbiati; Elisa Ballarini; Donato Calabrese; Maria Santos-Galindo; Roberta Rigolio; Marzia Pesaresi; Donatella Caruso; Barbara Viviani; Guido Cavaletti; Luis Miguel Garcia-Segura; Roberto Cosimo Melcangi
Journal:  J Neuroimmune Pharmacol       Date:  2012-06-30       Impact factor: 4.147

2.  Effect on Cognition of Estroprogestins Combined with Interferon Beta in Multiple Sclerosis: Analysis of Secondary Outcomes from a Randomised Controlled Trial.

Authors:  Laura De Giglio; Fabiana Marinelli; Valeria T Barletta; Veronica A Pagano; Floriana De Angelis; Fulvia Fanelli; Nikolaos Petsas; Patrizia Pantano; Valentina Tomassini; Carlo Pozzilli
Journal:  CNS Drugs       Date:  2017-02       Impact factor: 5.749

Review 3.  Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective.

Authors:  Sabrina Rahman Archie; Sejal Sharma; Elizabeth Burks; Thomas Abbruscato
Journal:  Neurotoxicology       Date:  2022-02-09       Impact factor: 4.294

4.  Structural sex differences at disease onset in multiple sclerosis patients.

Authors:  Juan Ignacio Rojas; Francisco Sánchez; Liliana Patrucco; Jimena Miguez; Jorge Funes; Edgardo Cristiano
Journal:  Neuroradiol J       Date:  2016-08-25

5.  Decreased spinal cord opioid receptor mRNA expression and antinociception in a Theiler's murine encephalomyelitis virus model of multiple sclerosis.

Authors:  Jessica L Lynch; Jeremy F Alley; Lori Wellman; Alvin J Beitz
Journal:  Brain Res       Date:  2007-11-28       Impact factor: 3.252

6.  Identification of sexually dimorphic gene expression in brain tissue of the fish Leporinus macrocephalus through mRNA differential display and real time PCR analyses.

Authors:  Fernanda A Alves-Costa; A P Wasko
Journal:  Genetica       Date:  2009-11-05       Impact factor: 1.082

Review 7.  Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis.

Authors:  Patrizia Casaccia-Bonnefil; Giovanna Pandozy; Fabrizio Mastronardi
Journal:  Prog Neurobiol       Date:  2008-09-26       Impact factor: 11.685

8.  Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis.

Authors:  Alessandro Massella; Giulia D'Intino; Mercedes Fernández; Sandra Sivilia; Luca Lorenzini; Silvia Giatti; Roberto C Melcangi; Laura Calzà; Luciana Giardino
Journal:  BMC Neurosci       Date:  2012-01-24       Impact factor: 3.288

9.  Oral contraceptives combined with interferon β in multiple sclerosis.

Authors:  Carlo Pozzilli; Laura De Giglio; Valeria T Barletta; Fabiana Marinelli; Floriana De Angelis; Valentina Gallo; Veronica A Pagano; Stefano Marini; Maria C Piattella; Valentina Tomassini; Patrizia Pantano
Journal:  Neurol Neuroimmunol Neuroinflamm       Date:  2015-06-18
  9 in total

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