Literature DB >> 16633336

Regulation of DNA repair by ubiquitylation.

Tony T Huang1, Alan D D'Andrea.   

Abstract

The process of ubiquitylation is best known for its role in targeting proteins for degradation by the proteasome. However, recent studies of DNA-repair and DNA-damage-response pathways have significantly broadened the scope of the role of ubiquitylation to include non-proteolytic functions of ubiquitin. These pathways involve the monoubiquitylation of key DNA-repair proteins that have regulatory functions in homologous recombination and translesion DNA synthesis, and involve the polyubiquitylation of nucleotide-excision-repair proteins.

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Year:  2006        PMID： 16633336     DOI： 10.1038/nrm1908

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  116 in total

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3.  Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.

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Journal:  EMBO J       Date:  2010-04-27       Impact factor: 11.598

Review 4.  Ubiquitin signalling in DNA replication and repair.

Authors:  Helle D Ulrich; Helen Walden
Journal:  Nat Rev Mol Cell Biol       Date:  2010-06-16       Impact factor: 94.444

5.  The interface between the ubiquitin family and the DNA damage response.

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Journal:  EMBO Rep       Date:  2010-11-12       Impact factor: 8.807

6.  Deubiquitylase, deSUMOylase, and deISGylase activity microarrays for assay of substrate preference and functional modifiers.

Authors:  Christian M Loch; Charles L Cuccherini; Craig A Leach; James E Strickler
Journal:  Mol Cell Proteomics       Date:  2010-10-18       Impact factor: 5.911

7.  SUMO-targeted ubiquitin ligases in genome stability.

Authors:  John Prudden; Stephanie Pebernard; Grazia Raffa; Daniela A Slavin; J Jefferson P Perry; John A Tainer; Clare H McGowan; Michael N Boddy
Journal:  EMBO J       Date:  2007-08-30       Impact factor: 11.598

8.  A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae.

Authors:  Hollie M Siebler; Artem G Lada; Andrey G Baranovskiy; Tahir H Tahirov; Youri I Pavlov
Journal:  DNA Repair (Amst)       Date:  2014-05-10

9.  Structural basis for role of ring finger protein RNF168 RING domain.

Authors:  Xiaoqin Zhang; Jie Chen; Minhao Wu; Huakai Wu; Aloysius Wilfred Arokiaraj; Chengliang Wang; Weichang Zhang; Yue Tao; Michael S Y Huen; Jianye Zang
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10.  Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.

Authors:  Stephanie Pebernard; J Jefferson P Perry; John A Tainer; Michael N Boddy
Journal:  Mol Biol Cell       Date:  2008-07-30       Impact factor: 4.138
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