| Literature DB >> 16632376 |
Abstract
Type 2 diabetes is rapidly becoming a worldwide epidemic. Obesity and sedentary lifestyle are the main environmental causes for the development of insulin resistance and type 2 diabetes. In the past decade, it has been increasingly recognized that obesity and insulin resistance are associated with chronic, low-grade systemic inflammation. This review will cover the recent advances in this field and provide a working model explaining how cellular inflammatory responses arise to cope with obesity-induced metabolic stresses and how these inflammatory responses underlie insulin resistance.Entities:
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Year: 2006 PMID： 16632376 DOI： 10.1016/j.phrs.2006.03.003
Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658