| Literature DB >> 16632355 |
Gilles C Bignan1, Kathleen Battista, Peter J Connolly, Michael J Orsini, Jingchun Liu, Steven A Middleton, Allen B Reitz.
Abstract
A novel series of indoles and 1H-pyrrolo[2,3-b]pyridines having a piperidine ring at the 3-position were synthesized and found to bind with high affinity to the ORL-1 receptor. Structure-activity relationships at the piperidine nitrogen were investigated in each series. Substitution on the phenyl ring and nitrogen atom of the indole and 1H-pyrrolo[2,3-b]pyridine cores generated several selective high-affinity ligands that were agonists of the ORL-1 receptor.Entities:
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Year: 2006 PMID： 16632355 DOI： 10.1016/j.bmcl.2006.03.094
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823