Literature DB >> 16631831

Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia.

Wenliang Chen1, Weidong Tang, Liguang Lou, Weimin Zhao.   

Abstract

2alpha,7beta,20alpha-Trihydroxy-3beta,21-dimethoxy-5-pregnene (1), 6,7,9alpha-trihydroxy-3,8,11alpha-trimethylcyclohexo-[d,e]-coumarin (2), 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid (3), and 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid methyl ester (4), along with 24 known compounds were isolated and structurally characterized from roots and aerial parts of Helicteres angustifolia (Sterculiaceae). In a preliminary bioassay, the two cucurbitacin derivatives, cucurbitacin D and J exhibited significant inhibitory activities against the growth of both hepatocellular carcinoma BEL-7402 cells and malignant melanoma SK-MEL-28 cells in vitro.

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Year:  2006        PMID： 16631831     DOI： 10.1016/j.phytochem.2006.03.005

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  6 in total

1.  Natural products from environmental DNA hosted in Ralstonia metallidurans.

Authors:  Jeffrey W Craig; Fang-Yuan Chang; Sean F Brady
Journal:  ACS Chem Biol       Date:  2009-01-16       Impact factor: 5.100

Review 2.  Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Authors:  Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2009-08-13       Impact factor: 13.423

3.  Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation.

Authors:  Juliana Oliveira de Melo; Laura Lícia Milani de Arruda; Silmara Baroni; Maria da Conceição Torrado Truiti; Silvana Martins Caparroz-Assef; Roberto Kenji Nakamura Cuman; Ciomar Aparecida Bersani-Amado
Journal:  Evid Based Complement Alternat Med       Date:  2011-10-19       Impact factor: 2.629

4.  Functional Characterisation of Anticancer Activity in the Aqueous Extract of Helicteres angustifolia L. Roots.

Authors:  Kejuan Li; Yue Yu; Shuang Sun; Ye Liu; Sukant Garg; Sunil C Kaul; Zhongfang Lei; Ran Gao; Renu Wadhwa; Zhenya Zhang
Journal:  PLoS One       Date:  2016-03-24       Impact factor: 3.240

5.  Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-κB and STAT3 Signaling.

Authors:  Dan Su; Yu-Qiao Gao; Wei-Bo Dai; Ying Hu; Yan-Fen Wu; Quan-Xi Mei
Journal:  Evid Based Complement Alternat Med       Date:  2017-02-26       Impact factor: 2.629

6.  New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae).

Authors:  Diégina A Fernandes; Maria S R Souza; Yanna C F Teles; Louise H G Oliveira; Jéssica B Lima; Adilva S Conceição; Fabíola C Nunes; Tania M S Silva; Maria de Fátima Vanderlei de Souza
Journal:  Molecules       Date:  2018-10-27       Impact factor: 4.411
  6 in total

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