| Literature DB >> 16631620 |
Wataru Mitsuma1, Masahiro Ito, Makoto Kodama, Koichi Fuse, Kazuki Okamura, Shiro Minagawa, Kiminori Kato, Haruo Hanawa, Ken Toba, Mikio Nakazawa, Yoshifusa Aizawa.
Abstract
Erythropoietin (EPO) has been known to have cytoprotective effects on several types of tissues, presumably through modulation of apoptosis and inflammation. The effect of EPO on myocardial inflammation, however, has not yet been clarified. We investigated the cardioprotective effects of EPO in rats with experimental autoimmune myocarditis (EAM). Seven-week-old Lewis rats immunized with cardiac myosin were treated either with EPO or vehicle and were examined on day 22. EPO attenuated the functional and histological severity of EAM along with suppression of mRNAs of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in the hearts as well as a reduction of apoptotic cardiomyocytes. The EPO receptor (EPO-R) was upregulated in the myocardium of EAM compared with that of healthy rats. These results may suggest that EPO ameliorated the progression of EAM by modulating myocardial inflammation and apoptosis.Entities:
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Year: 2006 PMID： 16631620 DOI： 10.1016/j.bbrc.2006.03.230
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575