| Literature DB >> 16631477 |
Biljana Todorić-Zivanović1, Dragomir Marisavljević, Cecilia Surace, Vesna Cemerikić, Olivera Marković, Koviljka Krtolica, Zeljka Tatomirović, Bojana Cikota, Zvonko Magić, Mariano Rocchi.
Abstract
Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Cryptic or "masked" BCR/ABL gene rearrangements may be found in cases with a normal karyotype and in cases with the complex karyotype, in which typical t(9;22) is not visible at the microscopic level. Those rearrangements can now be detected by fluorescence in situ hybridization. Here, we report on a novel and complex Ph chromosome-negative CML case with a t(6;9)(p21;q34.1) in which the BCR/ABL fusion gene is located at 6p21.Entities:
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Year: 2006 PMID： 16631477 DOI： 10.1016/j.cancergencyto.2005.11.008
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608