| Literature DB >> 16630812 |
Michael Buszczak1, Allan C Spradling.
Abstract
Stem cells encapsulate the fundamental problem of metazoan biology in miniature: How do cells establish and maintain their fates? Increasing evidence indicates that stem cell chromatin activates proliferation genes and represses differentiation genes. Understanding how these configurations are stabilized by Polycomb group proteins will advance our understanding of embryonic development, tissue homeostasis, regeneration, aging, and oncogenesis.Entities:
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Year: 2006 PMID： 16630812 DOI： 10.1016/j.cell.2006.04.004
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582