| Literature DB >> 16630811 |
Derrick J Rossi1, Irving L Weissman.
Abstract
Self-renewal pathways crucial for maintaining stem cells are deregulated in cancer, raising the spectre that cancer therapies targeting such pathways might also ablate normal stem cells. As Yilmaz et al. (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms.Entities:
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Year: 2006 PMID： 16630811 DOI： 10.1016/j.cell.2006.04.006
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582