| Literature DB >> 16630723 |
Kazuki Shimizu1, Akira Kawase, Tsuyoshi Haneishi, Yasuharu Kato, Kazutomo Kinoshita, Masayuki Ohmori, Yoshiyuki Furuta, Takashi Emura, Nobuaki Kato, Tetsuya Mitsui, Koji Yamaguchi, Keiichi Morita, Nobuo Sekiguchi, Tessai Yamamoto, Tomochika Matsushita, Shin Shimaoka, Atsuko Sugita, Kazumi Morikawa.
Abstract
Design, synthesis, and in vitro and in vivo evaluation of a series of antipsoriatic antedrugs having 16-en-22-oxa-vitamin D3 are described. Among the seven compounds examined, two are promising: ester 5c and amide 5f, both of which exhibit greater potent antiproliferation activity with lessened calcemic activity than the presently prescribed maxacalcitol (2).Entities:
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Year: 2006 PMID： 16630723 DOI： 10.1016/j.bmcl.2006.03.014
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823