Literature DB >> 16629409

Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25.

Ryuji Uchida1, Yong-Pil Kim, Ichiji Namatame, Hiroshi Tomoda, Satoshi Omura.   

Abstract

Sespendole was isolated as an inhibitor of lipid droplet formation in macrophages from the culture broth of a fungal strain Pseudobotrytis terrestris FKA-25. The compound inhibited the synthesis of cholesteryl ester and triacylglycerol by mouse macrophages with IC50 values of 4.0 and 3.2 microM, respectively.

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Year:  2006        PMID： 16629409     DOI： 10.1038/ja.2006.13

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  High-throughput screening of Australian marine organism extracts for bioactive molecules affecting the cellular storage of neutral lipids.

Authors:  James Rae; Frank Fontaine; Angela A Salim; Harriet P Lo; Robert J Capon; Robert G Parton; Sally Martin
Journal:  PLoS One       Date:  2011-08-08       Impact factor: 3.240

2.  Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families.

Authors:  Zhanchao Meng; Haixin Yu; Li Li; Wanyin Tao; Hao Chen; Ming Wan; Peng Yang; David J Edmonds; Jin Zhong; Ang Li
Journal:  Nat Commun       Date:  2015-02-04       Impact factor: 14.919

3.  New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440.

Authors:  Elyza Aiman Azizah Nur; Keisuke Kobayashi; Ai Amagai; Taichi Ohshiro; Hiroshi Tomoda
Journal:  Molecules       Date:  2020-07-06       Impact factor: 4.411

Review 4.  Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup.

Authors:  Jesús G Zorrilla; Antonio Evidente
Journal:  Biomolecules       Date:  2022-07-24

5.  Secondary Metabolites from the Endoparasitic Nematophagous Fungus Harposporium anguillulae YMF 1.01751.

Authors:  Zebao Dai; Yang Gan; Peiji Zhao; Guohong Li
Journal:  Microorganisms       Date:  2022-07-31

6.  A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction.

Authors:  Keisuke Kobayashi; Satoshi Ohte; Taichi Ohshiro; Narihiro Ugaki; Hiroshi Tomoda
Journal:  Sci Rep       Date:  2018-08-14       Impact factor: 4.379
  6 in total

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