Literature DB >> 16628200

MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis.

Eric F Morand1, Michelle Leech, Jürgen Bernhagen.   

Abstract

Macrophage migration inhibitory factor (MIF) is well established as a key cytokine in immuno-inflammatory diseases such as rheumatoid arthritis. Inflammation is now also recognized as having a crucial role in atherosclerosis, and recent evidence indicates that MIF could also be important in this disease. Here, we review the role of MIF in rheumatoid arthritis and atherosclerosis, discuss the ways in which MIF and its relationship with glucocorticoids could link these diseases, and consider the potential of MIF as a new therapeutic target for small-molecule and antibody-based anti-cytokine drugs.

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Year:  2006        PMID： 16628200     DOI： 10.1038/nrd2029

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  134 in total

1.  Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF).

Authors:  Alissa A Hare; Lin Leng; Sunilkumar Gandavadi; Xin Du; Zoe Cournia; Richard Bucala; William L Jorgensen
Journal:  Bioorg Med Chem Lett       Date:  2010-08-03       Impact factor: 2.823

Review 2.  Minireview: latest perspectives on antiinflammatory actions of glucocorticoids.

Authors:  Karolien De Bosscher; Guy Haegeman
Journal:  Mol Endocrinol       Date:  2008-12-18

3.  MIF and autophagy: a novel link beyond "eating".

Authors:  Omar El Bounkari; Jürrgen Bernhagen
Journal:  Cell Res       Date:  2012-05-08       Impact factor: 25.617

4.  Macrophage migration inhibitory factor is essential for osteoclastogenic mechanisms in vitro and in vivo mouse model of arthritis.

Authors:  Ran Gu; Leilani L Santos; Devi Ngo; HuaPeng Fan; Preetinder P Singh; Gunter Fingerle-Rowson; Richard Bucala; Jiake Xu; Julian M W Quinn; Eric F Morand
Journal:  Cytokine       Date:  2015-01-31       Impact factor: 3.861

5.  Novel half-life extended anti-MIF nanobodies protect against endotoxic shock.

Authors:  Amanda Sparkes; Patrick De Baetselier; Lea Brys; Inês Cabrito; Yann G-J Sterckx; Steve Schoonooghe; Serge Muyldermans; Geert Raes; Richard Bucala; Peter Vanlandschoot; Jo A Van Ginderachter; Benoît Stijlemans
Journal:  FASEB J       Date:  2018-01-25       Impact factor: 5.191

6.  Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002.

Authors:  C Herder; N Klopp; J Baumert; M Müller; N Khuseyinova; C Meisinger; S Martin; T Illig; W Koenig; B Thorand
Journal:  Diabetologia       Date:  2007-08-22       Impact factor: 10.122

7.  Independent roles of macrophage migration inhibitory factor and endogenous, but not exogenous glucocorticoids in regulating leukocyte trafficking.

Authors:  Julia L Gregory; Pam Hall; Michelle Leech; Eric F Morand; Michael J Hickey
Journal:  Microcirculation       Date:  2009-11       Impact factor: 2.628

8.  Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment.

Authors:  Christian Weber; Sandra Kraemer; Maik Drechsler; Hongqi Lue; Rory R Koenen; Aphrodite Kapurniotu; Alma Zernecke; Jürgen Bernhagen
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-13       Impact factor: 11.205

9.  Influence of the MIF polymorphism -173G > C on Turkish postmenopausal women with osteoporosis.

Authors:  A Z Ozsoy; N Karakus; S Tural; S Yigit; N Kara; G Alayli; M K Tumer; O Kuru
Journal:  Z Rheumatol       Date:  2018-09       Impact factor: 1.372

10.  Structures of Leishmania major orthologues of macrophage migration inhibitory factor.

Authors:  Julia M Richardson; Lesley S Morrison; Nicholas D Bland; Sandra Bruce; Graham H Coombs; Jeremy C Mottram; Malcolm D Walkinshaw
Journal:  Biochem Biophys Res Commun       Date:  2009-01-31       Impact factor: 3.575
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