INTRODUCTION: Paraneoplastic neurological disorders are a well recognized complication of malignancy. METHODS: A case report to expand the currently described clinical manifestations of type 1 antineuronal antibody (ANNA-1)-associated paraneoplastic encephalomyelitis to include coma. RESULTS: We present an unusual case of fluctuating coma and rapid fulminant progression to acute respiratory failure from central alveolar hypoventilation caused by ANNA-1 paraneoplastic encephalomyelitis associated with small-cell lung carcinoma. Paraneoplastic infiltration of the brainstem and cerebellum, including respiratory and arousal centers, was documented on autopsy. CONCLUSIONS: Paraneoplastic encephalomyelitis should be considered as a possible cause of coma and central alveolar hypoventilation.
INTRODUCTION:Paraneoplastic neurological disorders are a well recognized complication of malignancy. METHODS: A case report to expand the currently described clinical manifestations of type 1 antineuronal antibody (ANNA-1)-associated paraneoplastic encephalomyelitis to include coma. RESULTS: We present an unusual case of fluctuating coma and rapid fulminant progression to acute respiratory failure from central alveolar hypoventilation caused by ANNA-1 paraneoplastic encephalomyelitis associated with small-cell lung carcinoma. Paraneoplastic infiltration of the brainstem and cerebellum, including respiratory and arousal centers, was documented on autopsy. CONCLUSIONS:Paraneoplastic encephalomyelitis should be considered as a possible cause of coma and central alveolar hypoventilation.
Authors: F Graus; F Keime-Guibert; R Reñe; B Benyahia; T Ribalta; C Ascaso; G Escaramis; J Y Delattre Journal: Brain Date: 2001-06 Impact factor: 13.501
Authors: S Norris; S Rajendiran; K Sheahan; S Murphy; D Royston; R Alyusuf; M Farrell; P A McCormick Journal: Am J Gastroenterol Date: 1997-10 Impact factor: 10.864
Authors: Manuel J Gómez-Choco; Juan J Zarranz; Albert Saiz; María I Forcadas; Francesc Graus Journal: J Neurol Neurosurg Psychiatry Date: 2007-10 Impact factor: 10.154