Literature DB >> 16627257

The presence of anti-phosphatidylserine/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus.

Junzo Nojima1, Yoshinori Iwatani, Etsuji Suehisa, Hirohiko Kuratsune, Yuzuru Kanakura.   

Abstract

In an effort to clarify the clinical significance of anti-phospholipid antibodies (aPL) detected by enzyme-linked immunosorbent assay (ELISA), we examined the prevalence of anti-cardiolipin antibodies (aCL), anti-beta2-glycoprotein I antibodies (anti-beta2-GPI), antiprothrombin antibodies (anti-PT), and anti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) in 175 patients with systemic lupus erythematosus (SLE) comprising 67 patients with thrombotic complications. The present study showed that positive results of anti-beta2-GPI-ELISA and anti-PS/PT-ELISA could serve as markers of thrombotic complications in patients with SLE, whereas aCL and anti-PT are less reliable as markers of these complications. Furthermore, results of the anti-PS/PT-ELISA correlate best with the occurrence of both arterial and venous thrombosis in patients with SLE.

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Year:  2006        PMID： 16627257

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  15 in total

1.  Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies.

Authors:  Olga Amengual; Tetsuya Horita; Walter Binder; Gary L Norman; Zakera Shums; Masaru Kato; Kotaro Otomo; Yuichiro Fujieda; Kenji Oku; Toshiyuki Bohgaki; Shinsuke Yasuda; Tatsuya Atsumi
Journal:  Rheumatol Int       Date:  2014-02-05       Impact factor: 2.631

2.  Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus.

Authors:  F Yesim K Demirci; Amy S Dressen; Candace M Kammerer; M Michael Barmada; Amy H Kao; Rosalind Ramsey-Goldman; Susan Manzi; M Ilyas Kamboh
Journal:  J Rheumatol       Date:  2011-01-15       Impact factor: 4.666

Review 3.  The clinical significance of coagulation and the inflammatory response in autoimmunity.

Authors:  Benjamín Rubio-Jurado; Paulina Iñiguez-Franco; Pedro A Reyes; Gustavo Robles; Mario Salazar-Páramo; Guadalupe Zavala-Cerna; Carlos Riebeling; Arnulfo Nava
Journal:  Clin Rev Allergy Immunol       Date:  2012-04       Impact factor: 8.667

4.  Diagnostic value of antibodies to phosphatidylserine/prothrombin complex for antiphospholipid syndrome in Chinese patients.

Authors:  Lei Zhu; Chun Li; Na Liu; Xin Yang; R L Jia; Rong Mu; Yin Su; Z G Li
Journal:  Clin Rheumatol       Date:  2017-01-03       Impact factor: 2.980

5.  Lupus nephritis and Raynaud's phenomenon are significant risk factors for vascular thrombosis in SLE patients with positive antiphospholipid antibodies.

Authors:  Kittiwan Choojitarom; Orawan Verasertniyom; Kitti Totemchokchyakarn; Kanokrat Nantiruj; Vasant Sumethkul; Suchela Janwityanujit
Journal:  Clin Rheumatol       Date:  2007-09-02       Impact factor: 2.980

6.  Utility of antiphosphatidylserine/prothrombin and IgA antiphospholipid assays in systemic lupus erythematosus.

Authors:  Ehtisham Akhter; Zakera Shums; Gary L Norman; Walter Binder; Hong Fang; Michelle Petri
Journal:  J Rheumatol       Date:  2013-02-01       Impact factor: 4.666

7.  Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus.

Authors:  Tomoko Syuto; Akira Shimizu; Yuko Takeuchi; Setsuko Tanaka; Michiko Hasegawa; Yayoi Nagai; Atsushi Tamura; Osamu Ishikawa
Journal:  Clin Rheumatol       Date:  2009-02-18       Impact factor: 2.980

8.  The thrombophilic network of autoantibodies in celiac disease.

Authors:  Aaron Lerner; Nancy Agmon-Levin; Yinon Shapira; Boris Gilburd; Sandra Reuter; Idit Lavi; Yehuda Shoenfeld
Journal:  BMC Med       Date:  2013-04-04       Impact factor: 8.775

9.  Associations with thrombosis are stronger for antiphosphatidylserine/prothrombin antibodies than for the Sydney criteria antiphospholipid antibody tests in SLE.

Authors:  Sahwa Elbagir; Giorgia Grosso; NasrEldeen A Mohammed; Amir I Elshafie; Elnour M Elagib; Agneta Zickert; Vivek Anand Manivel; Eleftheria Pertsinidou; Musa A M Nur; Iva Gunnarsson; Johan Rönnelid; Elisabet Svenungsson
Journal:  Lupus       Date:  2021-05-06       Impact factor: 2.911

10.  The role of anti-phosphatidylserine/prothrombin antibodies in thrombotic manifestations of systemic lupus erythematosus patients.

Authors:  Konstantinos Tselios; Alexandros Sarantopoulos; Ioannis Gkougkourellas; Panagiota Boura
Journal:  Front Neurol       Date:  2013-06-04       Impact factor: 4.003
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