| Literature DB >> 16626640 |
Sujean Choi1, Valarie Blake, Sara Cole, John D Fernstrom.
Abstract
Appetite suppressants lose efficacy when given chronically; the mechanisms are unknown. We gave male rats once-daily dl-fenfluramine (dl-FEN, 5 mg/kg, i.p.) injections for 15 days and measured mRNA expression of corticotropin releasing factor (CRF), neuropeptide Y (NPY) and proopiomelanocortin (POMC) in hypothalamic neurons on days 1, 2 and 15. dl-FEN decreased food intake on days 1-2 but not on day 15. The drug increased CRF mRNA and decreased NPY mRNA on days 1-2; on day 15, NPY mRNA was normal, but CRF mRNA remained elevated. No changes occurred in POMC mRNA. Thus, only the NPY mRNA response to dl-FEN correlated with changes in food intake over time in a manner consistent with the known effects of NPY on food intake.Entities:
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Year: 2006 PMID： 16626640 DOI： 10.1016/j.brainres.2006.02.129
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252