Literature DB >> 16625001

Identification of an oculomotor biomarker of preclinical Huntington disease.

C V P Golding1, C Danchaivijitr, T L Hodgson, S J Tabrizi, C Kennard.   

Abstract

The authors examined oculomotor function to identify a biomarker of disease progression in genetically confirmed preclinical and early clinical Huntington disease (HD). Initiation deficits of voluntary-guided, but not reflexive, saccades were characteristic of preclinical HD. Saccadic slowing and delayed reflexive saccades were demonstrated in clinical but not preclinical HD. Saccadic measures provide biomarkers of disease progression in both preclinical and early clinical stages of HD.

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Year:  2006        PMID： 16625001     DOI： 10.1212/01.wnl.0000218215.43328.88

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  32 in total

1.  Huntington's disease: changes in saccades and hand-tapping over 3 years.

Authors:  Chrystalina A Antoniades; Zheyu Xu; Sarah L Mason; R H S Carpenter; Roger A Barker
Journal:  J Neurol       Date:  2010-06-29       Impact factor: 4.849

Review 2.  Disorders of saccades.

Authors:  Matthew J Thurtell; Robert L Tomsak; R John Leigh
Journal:  Curr Neurol Neurosci Rep       Date:  2007-09       Impact factor: 5.081

3.  Visual scanning and cognitive performance in prediagnostic and early-stage Huntington's disease.

Authors:  Tanya Blekher; Marjorie R Weaver; Jeanine Marshall; Siu Hui; Jacqueline Gray Jackson; Julie C Stout; Xabier Beristain; Joanne Wojcieszek; Robert D Yee; Tatiana M Foroud
Journal:  Mov Disord       Date:  2009-03-15       Impact factor: 10.338

4.  Multicenter validation of a bedside antisaccade task as a measure of executive function.

Authors:  J Hellmuth; J Mirsky; H W Heuer; A Matlin; A Jafari; S Garbutt; M Widmeyer; A Berhel; L Sinha; B L Miller; J H Kramer; A L Boxer
Journal:  Neurology       Date:  2012-05-09       Impact factor: 9.910

5.  Early Detection of Huntington Disease.

Authors:  Jane S Paulsen
Journal:  Future Neurol       Date:  2010-01

6.  Reflexive and volitional saccades: biomarkers of Huntington disease severity and progression.

Authors:  Saumil S Patel; Joseph Jankovic; Ashley J Hood; Cameron B Jeter; Anne B Sereno
Journal:  J Neurol Sci       Date:  2011-10-21       Impact factor: 3.181

7.  Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study.

Authors:  Kevin M Biglan; Christopher A Ross; Douglas R Langbehn; Elizabeth H Aylward; Julie C Stout; Sarah Queller; Noelle E Carlozzi; Kevin Duff; Leigh J Beglinger; Jane S Paulsen
Journal:  Mov Disord       Date:  2009-09-15       Impact factor: 10.338

8.  Eye-head coordination in moderately affected Huntington's Disease patients: do head movements facilitate gaze shifts?

Authors:  W Becker; R Jürgens; J Kassubek; D Ecker; B Kramer; B Landwehrmeyer
Journal:  Exp Brain Res       Date:  2008-09-20       Impact factor: 1.972

9.  The functional oculomotor network and saccadic cognitive control in healthy elders.

Authors:  Judy Pa; Shubir Dutt; Jacob B Mirsky; Hilary W Heuer; Paul Keselman; Erwin Kong; Andrew Trujillo; Adam Gazzaley; Joel H Kramer; William W Seeley; Bruce L Miller; Adam L Boxer
Journal:  Neuroimage       Date:  2014-03-24       Impact factor: 6.556

Review 10.  Functional neuroanatomy of the human premotor oculomotor brainstem nuclei: insights from postmortem and advanced in vivo imaging studies.

Authors:  Udo Rüb; Joanna C Jen; Heiko Braak; Thomas Deller
Journal:  Exp Brain Res       Date:  2008-04-02       Impact factor: 1.972
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