Literature DB >> 16624255

Regulation of aquaporin-2 trafficking and its binding protein complex.

Yumi Noda1, Sei Sasaki.   

Abstract

Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane is critical to water reabsorption in renal collecting ducts and its regulation maintains body water homeostasis. However, exact molecular mechanisms which recruit AQP2 are unknown. Recent studies highlighted a key role for spatial and temporal regulation of actin dynamics in AQP2 trafficking. We have recently identified AQP2-binding proteins which directly regulate this trafficking: SPA-1, a GTPase-activating protein (GAP) for Rap1, and cytoskeletal protein actin. In addition, a multiprotein "force generator" complex which directly binds to AQP2 has been discovered. This review summarizes recent advances related to the mechanism for AQP2 trafficking.

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Year:  2006        PMID： 16624255     DOI： 10.1016/j.bbamem.2006.03.004

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  37 in total

1.  EHD4 is a novel regulator of urinary water homeostasis.

Authors:  Shamma S Rahman; Alexandra E J Moffitt; Andrew J Trease; Kirk W Foster; Matthew D Storck; Hamid Band; Erika I Boesen
Journal:  FASEB J       Date:  2017-08-04       Impact factor: 5.191

2.  Depolymerization of cortical actin inhibits UT-A1 urea transporter endocytosis but promotes forskolin-stimulated membrane trafficking.

Authors:  Gang Xu; Hua Su; Conner B Carter; Otto Fröhlich; Guangping Chen
Journal:  Am J Physiol Cell Physiol       Date:  2012-01-18       Impact factor: 4.249

Review 3.  A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule.

Authors:  Sylvain Pradervand; Annie Zuber Mercier; Gabriel Centeno; Olivier Bonny; Dmitri Firsov
Journal:  Pflugers Arch       Date:  2010-08-05       Impact factor: 3.657

4.  Differential localization of aquaporin-2 and glucose transporter 4 in polarized MDCK cells.

Authors:  Takahiro Hasegawa; Toshiyuki Matsuzaki; Yuki Tajika; Abduxukur Ablimit; Takeshi Suzuki; Takeo Aoki; Haruo Hagiwara; Kuniaki Takata
Journal:  Histochem Cell Biol       Date:  2007-01-06       Impact factor: 4.304

5.  Phosphorylation of aquaporin-2 regulates its water permeability.

Authors:  Kayoko Eto; Yumi Noda; Saburo Horikawa; Shinichi Uchida; Sei Sasaki
Journal:  J Biol Chem       Date:  2010-10-22       Impact factor: 5.157

6.  Translocation of aquaporin-containing vesicles to the plasma membrane is facilitated by actomyosin relaxation.

Authors:  Christoph Riethmüller; Hans Oberleithner; Marianne Wilhelmi; Jonas Franz; Eberhard Schlatter; Jens Klokkers; Bayram Edemir
Journal:  Biophys J       Date:  2007-11-02       Impact factor: 4.033

Review 7.  The role of actin remodeling in the trafficking of intracellular vesicles, transporters, and channels: focusing on aquaporin-2.

Authors:  Yumi Noda; Sei Sasaki
Journal:  Pflugers Arch       Date:  2007-12-08       Impact factor: 3.657

8.  Acute rejection modulates gene expression in the collecting duct.

Authors:  Bayram Edemir; Stefan Reuter; Reka Borgulya; Rita Schröter; Ute Neugebauer; Gert Gabriëls; Eberhard Schlatter
Journal:  J Am Soc Nephrol       Date:  2008-01-23       Impact factor: 10.121

Review 9.  Aquaporins in kidney pathophysiology.

Authors:  Yumi Noda; Eisei Sohara; Eriko Ohta; Sei Sasaki
Journal:  Nat Rev Nephrol       Date:  2010-01-26       Impact factor: 28.314

10.  Localization of aquaporin-2, renal morphology and urine composition in the bottlenose dolphin and the Baird's beaked whale.

Authors:  Miwa Suzuki; Naoko Endo; Yuichi Nakano; Haruhiko Kato; Toshiya Kishiro; Kiyoshi Asahina
Journal:  J Comp Physiol B       Date:  2007-09-02       Impact factor: 2.200
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