| Literature DB >> 16623593 |
Abstract
[reaction: see text] A highly efficient alkynylation-cyclization of terminal alkynes with ortho-alkynylaryl aldehydes leading to 1-alkynyl-1H-isochromenes was developed by using a gold-phosphine complex as catalyst in water. The reaction was dually promoted by an electron-donating phosphine ligand and water and was chelation-controlled.Entities:
Year: 2006 PMID: 16623593 DOI: 10.1021/ol060645p
Source DB: PubMed Journal: Org Lett ISSN: 1523-7052 Impact factor: 6.005